Porous　organic　cages　(POCs)　have　shown　great　potential　in　many　applications,　and　post-synthetic　modification　(PSM)　has　been　confirmed　to　be　an　effective　strategy　to　tailor　their　structures　and　related　functionalities.　However,　it　is　extremely　challenging　to　develop　a　general　platform　for　simple-to-make　functional　POCs　for　advanced　applications　by　PSM　method.　Herein,　we　reported　that　octahedral　calix[4]resorcinarene-based　hydrazone-linked　porous　organic　cage　(HPOC-401)　provides　an　excellent　platform　for　post-synthetic　metalation　by　various　transition　metal　(TM)　ions　under　mild　conditions　due　to　the　abundance　of　coordination　sites　in　its　skeleton.　Such　metalated　products　(HPOC-401-TM)　exhibit　Brunauer-Emmett-Teller　(BET)　surface　area　up　to　1,456　m2　g−1,　much　higher　than　that　of　the　pristine　HPOC-401,　which　has　a　BET　value　of　474　m2　g−1.　Moreover,　the　metalation　and　porosity　increases　further　influence　their　gas　capture,　separation,　as　well　as　catalytic　performance.　For　instance,　HPOC-401-TM　products　exhibit　higher　CO2,　H2,　and　C2　hydrocarbon　gas　uptake,　as　well　as　higher　C2H6/C2H4　selectivity　than　HPOC-401.　Moreover,　the　HPOC-401-TM　also　shows　better　catalytic　performance　in　the　cycloaddition　of　CO2　with　epoxides　compared　to　HPOC-401.　These　findings　uncover　a　simple　yet　effective　approach　for　modifying　the　porosity　characteristics　of　organic　cages,　which　will　undoubtedly　expand　their　future　implementations.　[Figure　not　available:　see　fulltext.]　©　2023,　Science　China　Press.