Inspired　by　the　double-helix　structure　of　biological　DNA,　low-volume　fraction　and　high-strength　Al2O3　twisted　honeycomb　structures　with　characteristics　similar　to　those　of　helical　structures　in　the　z-axis　were　prepared　by　digital　light　processing　3D　printing　technology.　As　the　twist　angle　increased,　the　compressive　strength　of　the　fabricated　Al2O3　structure　decreased,　and　the　deformation　mechanism　of　the　Al2O3　structures　gradually　changed　from　stretching-dominated　to　bending-dominated,　which　can　be　predicted　by　the　Gibson–Ashby　model.　The　relationship　between　the　effective　elastic　modulus　and　the　volume　fraction　that　can　be　modified　by　varying　the　wall　thickness　was　described　by　the　Pabst–Gregorova　exponential　relationship.　The　compressive　strength　of　the　Al2O3　structure　with　a　twist　angle　of　0°　can　reach　62.4　MPa　at　a　volume　fraction　of　13.3%,　providing　guidance　to　optimize　lightweight　structures　of　ceramics.　©　2023　Elsevier　Ltd　and　Techna　Group　S.r.l.