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author:

Wang, Haihui (Wang, Haihui.) [1] | Jiang, Yifan (Jiang, Yifan.) [2] | Liu, Yichang (Liu, Yichang.) [3] | Zhu, Xiaohui (Zhu, Xiaohui.) [4] | Liu, Yongfei (Liu, Yongfei.) [5] | Chen, Minle (Chen, Minle.) [6] | Zeng, Tao (Zeng, Tao.) [7] | Chen, Zhaowei (Chen, Zhaowei.) [8] | Li, Jinyu (Li, Jinyu.) [9] | Lu, Chunhua (Lu, Chunhua.) [10] | Yang, Huanghao (Yang, Huanghao.) [11]

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EI

Abstract:

The physicochemical differences between DNA and other molecules pose a challenge to the construction of DNA-based nanostructures. Herein, we propose a straightforward approach for preparing multifunctional DNA-based nanospheres through direct self-assembly of 2′-fluoro-substituted single-stranded DNA (2′F-DNA) with various small molecules. Molecular dynamics simulation revealed that 2′F substitution in DNA can cause the repulsion of adjacent PO43- group, leading to local stretching of the DNA structure. Moreover, 2′F substituent induced the regular polarization of H2O nearby F to form the hydration layer, which interrupts inherent interactions among bases. In this way, the bases of 2′F-DNA chain have fewer constraints and more flexibility in conformation, facilitating their non-covalent interactions with other molecules and enhancing the self-assembly capacity of 2′F-DNA. Consequently, 2′F-DNA can bind to more molecules, tending to spontaneously form hybrid DNA nanospheres. Following this approach, a chemo-gene therapy 2′F-DNA/doxorubicin model was designed, showing the significant synergistic anti-tumor therapeutic efficacy. Taken together, this study provides an expandable approach for constructing engineering hybrid nanospheres using DNA and other small molecules, which holds great potential for further biological applications. © 2023 Elsevier B.V.

Keyword:

Bioinformatics DNA Gene therapy Molecular dynamics Nanospheres Self assembly

Community:

  • [ 1 ] [Wang, Haihui]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou; 350116, China
  • [ 2 ] [Jiang, Yifan]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou; 350116, China
  • [ 3 ] [Liu, Yichang]National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, College of Chemistry, Fuzhou University, Fujian, Fuzhou; 350116, China
  • [ 4 ] [Zhu, Xiaohui]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou; 350116, China
  • [ 5 ] [Liu, Yongfei]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou; 350116, China
  • [ 6 ] [Chen, Minle]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou; 350116, China
  • [ 7 ] [Zeng, Tao]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou; 350116, China
  • [ 8 ] [Chen, Zhaowei]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou; 350116, China
  • [ 9 ] [Li, Jinyu]National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, College of Chemistry, Fuzhou University, Fujian, Fuzhou; 350116, China
  • [ 10 ] [Lu, Chunhua]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou; 350116, China
  • [ 11 ] [Yang, Huanghao]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou; 350116, China

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Source :

Chemical Engineering Journal

ISSN: 1385-8947

Year: 2023

Volume: 471

1 3 . 4

JCR@2023

1 3 . 4 0 0

JCR@2023

ESI HC Threshold:35

JCR Journal Grade:1

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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