Two　novel　dilacunary　gamma-Keggin-type　germanotungstates　namely　H-2[Cu(en)(2)](4)　{[Cu(en)(2)](3)[GeW10O36](2)}　(1),　H-4[Co(en)(3)](2)[GeW10O36]center　dot　2H(2)O　(2),　have　been　synthesized.　Under　visible　light　(lambda　＞=　420　nm)　irradiation,　compound　2　showed　excellent　photocatalytic　activity　against　rhodamine　B　(RhB),　and　the　degradation　efficiency　was　88.9%　at　pH　4.0,　which　was　8.5　times　and　1.4　times　higher　than　that　at　pH　7.0　and　1.0,　respectively.　Further　mechanism　study　revealed　that　pH　is　an　important　factor　affecting　the　photocatalytic　reaction.　The　anti-tumor　property　of　compounds　was　studied　as　the　first　case　for　[gamma-GeW10O36](8-)　cluster　anion　in　vitro.　Remarkably,　compound　1　has　excellent　anti-tumor　activities　against　liver　cancer　Huh7　(IC50,　26.18　mu　M),　colon　cancer　SW480　(IC50,　28.36　mu　M)　and　gastric　cancer　HGC-27(IC50,　41.31　mu　M)　with　half　maximal　inhibitory　concentration　(IC50)　less　than　50　mu　M.　The　relationship　between　structure　and　biology　activity　indicates　that　the　H-bonding　interactions　may　influence　the　anti-tumor　activity.　This　novel　difunctional　germanotungstates　not　only　provides　a　clue　for　development　of　high-efficiency　photocatalysts　but　also　highlights　a　promising　strategy　to　construct　antitumor　germanotungstates-type　drug.