Piezo-catalysis　represents　a　promising　and　environmentally-friendly　technology　for　dye　degradation,　but　the　commonly　used　BaTiO3　piezoelectric　material　still　face　bottleneck　of　relative　low　piezo-catalytic　activity.　Enhancement　of　its　catalytic　activity　via　diversified　means　is　crucial　for　improving　the　degradation　efficiency　and　implementation　of　water　treatment.　In　this　study,　we　synthesized　Ba1-xSrxTiO3　nanoparticles　utilizing　the　sol-gel　method.　The　highest　catalytic　performance　for　degrading　rhodamine　B　is　at　x　=　0.15　through　the　piezo-photocatalytic　synergy,　displaying　a　degradation　rate　of　92.66　%　within　18　min　and　an　impressive　reaction　rate　of　14.26　x　10(-2)　min(-1),　surpassing　most　of　other　BaTiO3-based　materials.　Importantly,　the　nanoparticles　exhibited　excellent　catalytic　degradation　performance　for　a　variety　of　pollutants　under　different　environments.　In　addition,　it　is　confirmed　that　Sr2+　doping　can　enhance　the　catalytic　efficiency　via　three　pathways,　i.e.　modifying　energy　band　gap,　modulating　grain　size　as　well　as　Curie　temperature.　This　work　provides　a　convenient　strategy　for　the　rational　regulation　of　catalytic　performance　in　BaTiO3-based　piezoelectric　materials.