The　selective　partial　oxidation　of　methane　to　methanol　using　molecular　oxygen　(O-2)　represents　a　long-standing　challenge,　inspiring　extensive　study　for　many　decades.　However,　considerable　challenges　still　prevent　low-temperature　methane　activation　via　the　aerobic　route.　Here　we　report　a　precipitated　Pd-containing　phosphomolybdate,　which,　after　activation　by　molecular　hydrogen　(H2),　converts　methane　and　O-2　almost　exclusively　to　methanol　at　room　temperature.　The　highest　activity　reaches　67.4　mu　mol　gcat(-1)　h(-1).　Pd　enables　rapid　H-2　activation　and　H　spillover　to　phosphomolybdate　for　Mo　reduction,　while　facile　O-2　activation　and　subsequent　methane　activation　occur　on　the　reduced　phosphomolybdate　sites.　Continuous　production　of　methanol　from　methane　was　also　achieved　by　concurrently　introducing　H-2,　O-2　and　methane　into　the　system,　where　H-2　assists　in　maintaining　a　moderately　reduced　state　of　phosphomolybdate.　This　work　reveals　the　underexplored　potential　of　such　a　Mo-based　catalyst　for　aerobic　methane　oxidation　and　highlights　the　importance　of　regulating　the　chemical　valence　state　to　construct　methane　active　sites.