Purpose:　The　influence　of　resection　margin　(RM)　width　on　the　prognosis　of　solitary　hepatocellular　carcinoma　(HCC)　following　anatomical　resection　(AR)　has　yet　to　be　determined.　Therefore,　we　conducted　a　real-world　study　to　identify　the　optimal　RM　width　and　assess　its　impact　on　the　outcomes　of　solitary　HCC　patients　undergoing　AR.Methods:　The　data　pertaining　to　patients　diagnosed　with　solitary　HCC　who　underwent　AR　between　December　2012　and　December　2015　were　retrospectively　collected.　The　optimal　cutoff　value　for　the　width　of　the　RM　was　determined　using　X-tile　software.　The　Kaplan-Meier　method　was　utilized　to　compare　the　overall　survival　(OS)　and　disease-free　survival　(DFS)　between　the　narrow　and　wide　RM　groups.　Additionally,　propensity　score　matching　(PSM)　was　performed　to　minimize　potential　bias　in　the　data.Results:　Of　the　1033　patients　who　met　the　inclusion　criteria,　293　(28.4%)　were　categorized　into　the　narrow　RM　group　(＜=　4　mm)　and　740　(71.6%)　into　the　wide　RM　group　(＞　4mm).　Before　and　after　PSM,　there　were　no　significant　differences　in　OS　and　DFS　between　the　two　groups　(before　PSM:　OS,　HR=0.78,　P=0.071;　DFS,　HR=0.95,　P=0.620;　after　PSM:　OS,　HR=0.77,　P=0.150;　DFS,　HR=0.90,　P=0.470).　Multivariate　analysis　demonstrated　that　RM　width　was　not　an　independent　risk　factor　for　DFS　and　OS　both　before　and　after　PSM　(all　P＞0.05).　However,　subgroup　analyses　revealed　that　patients　with　ALBI　grade　1,　absence　of　cirrhosis,　and　AJCC　stage　II　significantly　benefited　from　wide　RM　in　OS　(all　P＜　0.05).　Similarly,　patients　without　HBV　infection　and　absence　of　cirrhosis　also　exhibited　significant　benefits　from　wide　RM　in　DFS　(both　P＜　0.05).Conclusion:　In　patients　with　solitary　HCC　undergoing　AR,　the　width　of　the　RM　does　not　appear　to　have　a　significant　impact　on　their　prognosis.　However,　in　certain　selected　patients,　a　wider　RM　may　confer　benefits.