Lithium-sulfur　(Li-S)　batteries　have　attracted　widespread　attention　because　of　their　high　energy　density,　low　cost　and　environmentally　friendly　nature.　Unfortunately,　the　practical　applicability　of　Li-S　batteries　is　seriously　restricted　by　the　shuttle　effect　and　sluggish　reaction　kinetics　of　soluble　lithium　polysulfides　(LiPSs).　Herein,　strong　topological　insulator　(TI)　Bi2Se3　and　weak　TI　BiSe　with　unique　cloud-like　hollow　structures　have　been　rationally　synthesized　and　employed　as　separator　modifiers　for　Li-S　batteries.　The　strong　TI　Bi2Se3　possesses　abundant　active　sites,　high　electrical　conductivity,　strong　chemical　adsorption,　superior　catalytic　activity　and　robust　surface　states,　which　significantly　accelerates　the　redox　conversion　kinetics,　mitigates　the　shuttle　effect　of　LiPSs　and　improves　the　sulfur　utilization.　Consequently,　Li-S　batteries　with　strong　TI　Bi2Se3　modified　separators　demonstrate　impressive　practical　prospects　in　terms　of　high　discharge　capacity　(1568.8　mA　h　g-1　at　0.1C),　remarkable　rate　capability　(866.3　mA　h　g-1　at　5.0C)　and　a　stable　capacity　of　524.3　mA　h　g-1　over　500　cycles　at　1C　(corresponding　to　a　capacity　decay　rate　of　0.086%).　The　performance　enhancements　are　further　supported　by　theoretical　calculations.　This　work　might　provide　valuable　insights　into　the　delicate　design　and　synthesis　of　TI　materials　with　desired　morphology　and　structure　to　boost　their　performance　for　energy　storage.　Topological　insulator　Bi2Se3　with　a　unique　cloud-like　hollow　structure　was　synthesized　and　employed　as　a　separator　modifier　for　lithium-sulfur　batteries,　which　can　significantly　accelerate　sulfur　conversion　kinetics　and　mitigate　the　shuttle　effect.