Tetracycline　(TC),　a　widely　employed　broad-spectrum　antibiotic　with　global　prevalence,　possesses　the　ability　to　infiltrate　soil　matrices　and　potentially　reach　groundwater　systems,　thereby　posing　a　consequential　human　health　risk.　To　address　this　concern,　a　novel　NiFe-mixed　metal　oxides　(MMO)　composite　was　synthesized　and　employed　within　quartz　sand　as　a　strategic　measure　to　regulate　the　downward　migration　of　TC.　In-depth　investigations　of　TC　transport　behavior　in　quartz　sand,　complemented　by　NiFe-MMO,　were　conducted　via　a　series　of　rigorous　batch　and　saturation-filled　column　experiments.　The　impacts　of　NiFe-MMO　dosage,　ionic　strength,　cationic　types,　solution　pH,　and　flow　rates　on　TC　transport　were　systematically　and　comprehensively　scrutinized.　Our　findings　reveal　that　even　minute　quantities　of　NiFe-MMO　prompt　substantial　TC　adsorption,　facilitated　by　electrostatic　interactions　and　surface　complexation,　notably　in　low-concentration　background　solutions.　Additionally,　the　presence　of　Ca2+　engenders　a　bridging　effect,　further　enhancing　TC　adsorption　onto　the　sand.　These　significant　observations　bear　far-reaching　implications　in　elucidating　the　fate　of　antibiotics　within　the　intricate　interplay　of　soil　and　groundwater　domains.　The　strategic　amalgamation　of　NiFe-MMO　and　quartz　sand　offers　innovative　prospects　for　managing　TC　dissemination,　thereby　augmenting　endeavors　toward　sustainable　environmental　protection.　©　2023　Elsevier　B.V.