The　＂shuttle　effect＂　of　soluble　lithium　polysulfides　(LiPSs)　in　lithium-sulfur　(Li-S)　batteries　can　lead　to　sluggish　kinetics　of　sulfur　redox　reactions　and　rapid　capacity　degradation,　significantly　limiting　the　practical　application　of　Li-S　batteries　on　a　large　scale.　Herein,　the　cascade　catalysis　is　achieved　based　on　a　self-recovery　catalyst　with　multiple　catalytic　centers　through　a　ZnIn2S4-In2O3-ZnIn2S4　sandwich-like　structure　to　realize　the　tandem　redox　of　S8　to　Li2S.　Specifically,　the　outer　ZnIn2S4　nanosheet　network　can　preferentially　adsorb　S8,　and　the　middle　In2O3　acts　as　an　adsorption　mediator　to　ensure　the　adsorption　and　conversion　of　S8　to　long-chain　Li2S6/Li2S4,　and　then　the　inner　ZnIn2S4　can　further　catalyze　the　conversions　from　long-chain　Li2S4　to　short-chain　Li2S2/Li2S.　Revers-ibly,　the　ZnIn2S4　is　better　in　decreasing　the　energy　barrier　of　Li2S　dissolution,　and　further　converting　it　into　elemental　sulfur　(S8).　During　this　process,　the　In/O　and　In/Zn　active　sites　are　re-exposed　by　alternating　catalytic　mode　to　achieve　the　self-recovery　of　active　site,　thereby　enhancing　long-term　catalytic　activity.　This　work　demonstrates　that　cascade　catalysis　can　be　achieved　by　self-recovery　catalysts　with　multiple　catalytic　centers　for　LiPSs,　providing　novel　insights　into　the　design　of　multi-functional　catalysts　to　rationally　regulate　LiPSs＇　redox　reactions