Benzocaine　(BZC)　is　a　widely　used　anaesthetic　drug　coupled　with　multiple　undesirable　side　effects,　thus　developing　sensitive　method　for　its　detection　is　of　great　importance;　meanwhile,　hollow　carbon　nanospheres　(HCS)　have　received　intense　interests　in　electroanalysis　resulted　from　its　unique　merits,　but　the　related　close　structures　restrain　the　availability　factor　of　the　internal　surfaces,　hence　suppressing　their　analytical　performance.　In　this　work,　a　novel　nanomaterial　with　open　structure,　hollow　carbon　nanobowl　(HCB)　was　prepared　and　adopted　as　the　electrode　material　for　fabricating　a　highly　sensitive　electrochemical　sensor　of　BZC.　The　obtained　results　revealed　the　as-prepared　HCB　can　display　more　superior　sensing　performance　than　conventional　HCS.　After　optimizing　various　experimental　conditions　including　the　modified　amount　of　HCB,　accumulation　time　and　the　buffer　pH　value,　the　detection　of　BZC　was　performed　at　HCB　modified　electrode,　and　a　considerably　low　detection　limit　(4.0　nM)　coupled　with　high　sensitivity　(2.1527　μA　μM−1)　was　obtained.　In　addition,　the　further　experiments　demonstrated　that　the　HCB　modified　electrode　possesses　superior　capability　in　repeatability,　stability,　selectivity　and　practical　application.　It＇s　thus　expected　that　the　as-designed　HCB-based　sensing　platform　has　important　application　for　BZC　and　other　targets　detection.　©　2023