Hypoxic　microenvironment　is　clinically　associated　with　metastasis　and　poor　prognosis　of　numerous　cancers.　The　mechanisms　by　which　intratumoral　hypoxia　regulates　metastasis　are　not　fully　understood.　Our　study　identifies　a　downregulation　of　Lnc-CSMD1-7　in　hepatocellular　carcinoma　(HCC)　and　correlated　with　poor　prognosis　of　HCC　patients.　Lnc-CSMD1-7　negatively　regulated　HCC　cell　migration　and　invasion　in　vitro　and　suppressed　lung　metastasis　in　vivo.　Mechanistically,　Lnc-CSMD1-7　directly　binds　to　RBFOX2,　thereby　affecting　RBFOX2-regulated　alternative　splicing　in　epithelial　and　mesenchymal-specific　events.　More　importantly,　hypoxic　microenvironment　and　m6A　methylation　mediate　the　downregulation　of　Lnc-CSMD1-7　expression.　Specifically,　hypoxia　transcriptionally　upregulates　the　expression　of　the　m6A　methyltransferase　METTL16　via　HIF-1　alpha,　and　METTL16　directly　binds　to　Lnc-CSMD1-7　and　downregulates　the　RNA　stability　of　Lnc-CSMD1-7　via　m6A　methylation,　ultimately　promoting　HCC　metastasis.　Our　findings　highlight　the　regulatory　function　of　the　METTL16/Lnc-CSMD1-7/RBFOX2　axis　in　modulating　hypoxia-induced　HCC　progression,　which　may　provide　potential　prognostic　and　therapeutic　targets　for　HCC　treatment.