Parsing　the　intricate　interplay　between　gut　microbiota,　gene　modulation,　and　host　metabolism　remains　challenging.　Wang　et　al.　employed　diverse　methods　to　uncover　how　the　gut　microbiota　reshapes　intestinal　lipid　metabolism　through　the　lncRNA　Snhg9,　underscoring　the　value　of　systems　biology　approaches　in　dissecting　host-microbiome　relationships　involved　in　metabolic　disorders.