Login | Cas Login
English| 简体中文| 繁体中文

  • Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

Advanced Search

author：

Fang, J. (Fang, J..) [1] | Wang, X. (Wang, X..) [2] | Cao, G. (Cao, G..) [3] | Wang, F. (Wang, F..) [4] | Ru, Y. (Ru, Y..) [5] | Wang, B. (Wang, B..) [6] | Zhang, Y. (Zhang, Y..) [7] | Zhang, D. (Zhang, D..) [8] | Yan, J. (Yan, J..) [9] | Xu, J. (Xu, J..) [10] | Ji, J. (Ji, J..) [11] | Ji, F. (Ji, F..) [12] | Zhou, Y. (Zhou, Y..) [13] | Guo, L. (Guo, L..) [14] | Li, M. (Li, M..) [15] | Liu, W. (Liu, W..) [16] | Cai, X. (Cai, X..) [17] | Cai, Z. (Cai, Z..) [18]

Indexed by：

Scopus

Abstract：

The　emerging　toxicant　N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine　quinone　(6PPD-Q)　is　of　wide　concern　due　to　its　ubiquitous　occurrence　and　high　toxicity.　Despite　regular　human　exposure,　limited　evidence　exists　about　its　presence　in　the　body　and　potential　health　risks.　Herein,　we　analyzed　cerebrospinal　fluid　(CSF)　samples　from　Parkinson＇s　disease　(PD)　patients　and　controls.　The　CSF　levels　of　6PPD-Q　were　twice　as　high　in　PD　patients　compared　to　controls.　Immunostaining　assays　performed　with　primary　dopaminergic　neurons　confirm　that　6PPD-Q　at　environmentally　relevant　concentrations　can　exacerbate　the　formation　of　Lewy　neurites　induced　by　α-synuclein　preformed　fibrils　(α-syn　PFF).　Assessment　of　cellular　respiration　reveals　a　considerable　decrease　in　neuronal　spare　respiratory　and　ATP-linked　respiration,　potentially　due　to　changes　in　mitochondrial　membrane　potential.　Moreover,　6PPD-Q-induced　mitochondrial　impairment　correlates　with　an　upsurge　in　mitochondrial　reactive　oxygen　species　(mROS),　and　Mito-TEMPO-driven　scavenging　of　mROS　can　lessen　the　amount　of　pathologic　phospho-serine　129　α-synuclein.　Untargeted　metabolomics　provides　supporting　evidence　for　the　connection　between　6PPD-Q　exposure　and　changes　in　neuronal　metabolite　profiles.　In-depth　targeted　metabolomics　further　unveils　an　overall　reduction　in　glycolysis　metabolite　pool　and　fluctuations　in　the　quantity　of　TCA　cycle　intermediates.　Given　its　potentially　harmful　attributes,　the　presence　of　6PPD-Q　in　human　brain　could　potentially　be　a　risk　factor　for　PD.　©　2023

Keyword：

Cerebrospinal fluid Metabolomics Mitochondrial respiration N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone α-synuclein preformed fibrils

Community：

  • [ 1 ] [Fang J.]State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong
  • [ 2 ] [Wang X.]State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong
  • [ 3 ] [Cao G.]State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong
  • [ 4 ] [Wang F.]State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong
  • [ 5 ] [Ru Y.]State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong
  • [ 6 ] [Wang B.]State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong
  • [ 7 ] [Zhang Y.]School of Ecology and Environment, Zhengzhou University, Henan, Zhengzhou, China
  • [ 8 ] [Zhang D.]Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Futian District, Guangdong, Shenzhen, China
  • [ 9 ] [Yan J.]Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Futian District, Guangdong, Shenzhen, China
  • [ 10 ] [Xu J.]The Central Laboratory, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Guangdong, Shenzhen, China
  • [ 11 ] [Ji J.]The Central Laboratory, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Guangdong, Shenzhen, China
  • [ 12 ] [Ji F.]Institute of Digestive Disease, Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong
  • [ 13 ] [Zhou Y.]State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong
  • [ 14 ] [Guo L.]Interdisciplinary Institute of Medical Engineering, Fuzhou University, Fujian, Fuzhou, China
  • [ 15 ] [Li M.]Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong
  • [ 16 ] [Liu W.]Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Futian District, Guangdong, Shenzhen, China
  • [ 17 ] [Cai X.]Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Futian District, Guangdong, Shenzhen, China
  • [ 18 ] [Cai Z.]State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong

Reprint 's Address：

Email：

Show more details

Related Keywords：

Related Article：

Source ：

Journal of Hazardous Materials

ISSN： 0304-3894

Year： 2024

Volume： 465

1 2 . 2 0 0

JCR@2023

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 3

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search SCOPUS
Online/Total：299/10042257
Address：FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code：350116) Contact Us：0591-22865326
Copyright：FZU Library Technical Support：Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1