Hydrogel　dressings　capable　of　infection　monitoring　and　precise　treatment　administration　show　promise　for　advanced　wound　care.　Existing　methods　involve　embedd　ingorganic　dyes　or　flexible　electronics　into　preformed　hydrogels,　which　raise　safety　issues　and　adaptability　challenges.　In　this　study,　an　injectable　hydrogel　based　smart　wound　dressing　is　developed　by　integrating　food-derived　anthocyanidin　as　a　visual　pH　probe　for　infection　monitoring　and　poly(L-lactic　acid)　microcapsules　as　ultrasound-responsive　delivery　systems　for　antibiotics　into　a　poly(ethylene　glycol)　hydrogel.　This　straightforwardly　prepared　hydrogel　dressing　maintains　its　favorable　properties　for　wound　repair,　including　porous　morphology　and　excellent　biocompatibility.　In　vitro　experiments　demonstrated　that　the　hydrogel　enabled　visual　assessment　of　pH　within　the　range　of　5 ∼ 9.Meanwhile,　the　release　of　antibiotics　could　be　triggered　and　controlled　by　ultrasound.　In　vivo　evaluations　using　infected　wounds　and　diabetic　wounds　revealed　that　the　wound　dressing　effectively　detected　wound　infection　by　monitoring　pH　levels　and　achieved　antibacterial　effects　through　ultrasound-triggered　drug　release.　This　led　to　significantly　enhanced　wound　healing,　as　validated　by　histological　analysis　and　the　measurement　of　inflammatory　cytokine　levels.　This　injectable　hydrogel-based　smart　wound　dressing　holds　great　potential　for　use　in　clinical　settings　to　inform　timely　and　precise　clinical　intervention　and　in　community　to　improve　wound　care　management.　©　2024　Wiley-VCH　GmbH.