With　the　increasing　demands　of　X-ray　detection　and　medical　diagnosis,　organic　scintillators　with　intense　and　tunable　X-ray　excited　emission　have　been　becoming　important.　To　guarantee　the　X-ray　absorption,　heavy　atoms　were　widely　added　in　reported　organic　scintillators,　which　led　to　emission　quenching.　In　this　work,　we　propose　a　new　strategy　to　realize　organic　scintillators　through　the　host-guest　doping　strategy.　Then　the　X-ray　absorption　centers　(host)　and　emission　centers　(guest)　are　separated.　Under　X-ray　excitation,　these　materials　displayed　intense　and　readily　tunable　emissions　ranging　from　green　(520　nm)　to　near　infrared　(NIR)　regions　(682　nm).　Besides,　the　relationship　between　the　X-ray　absorption　and　spatial　arrangement　of　the　heavy　atoms　in　the　host　matrix　was　also　revealed.　The　potential　application　of　these　wide-range　color　tunable　organic　host-guest　scintillators　in　X-ray　imaging　were　demonstrated.　This　work　provides　a　new　feasible　strategy　for　constructing　high-performance　organic　scintillators　with　tunable　luminescence　properties.　©　2023　Wiley-VCH　GmbH.