In　recent　years,　there　has　been　an　increasing　concern　for　health　and　food　safety　due　to　the　severe　environmental　pollution　caused　by　the　overuse　of　antibiotics　and　pesticides.　Effective　and　accurate　detection　of　these　species　is　of　great　importance　in　many　fields.　In　this　paper,　a　two-dimensional　lanthanide　organic　framework　[Tb(dobpdc)1.5(DEA)2]n　(1)　was　synthesized　using　4,4′-dihydroxy-3,3′-biphenyl　dicarboxylic　acid　ligand　(H2L)　with　Tb(III)　ion　in　the　atmosphere　of　N,N＇-diethylacetamide　(DEA)　and　deionized　water　as　solvents　by　solvothermal　method.　Compound　1　displays　a　single　excitation　double　emission　in　aqueous　suspensions.　The　luminescence　properties　of　1　were　exploited　as　a　multi-responsive　luminescence　sensor　for　nitrofuran　antibiotics　(nitrofurazone,　nitrofurantoin)　and　triazine　pesticides　(metamitron)　with　a　low　detection　limit　and　high　selectivity　via　dual　emission　＇turn-off＇　luminescence　quenching.　1　has　also　been　successfully　applied　to　the　construction　of　portable　test　strips　for　the　detection　of　antibiotics　and　pesticides.　In　addition,　the　mechanism　of　fluorescence　quenching　has　also　been　further　discussed.　©　2024　Elsevier　B.V.