Electromagnetic　metamaterials　feature　the　capability　of　squeezing　photons　into　hotspot　regions　of　high　intensity　near-field　enhancement　for　strong　light-matter　interaction,　underpinning　the　next　generation　of　emerging　biosensors.　However,　randomly　dispersed　biomolecules　around　the　hotspots　lead　to　weak　interactions.　Here,　we　demonstrate　an　all-silicon　dielectric　terahertz　metamaterial　sensor　design　capable　of　passively　trapping　biomoleculars　into　the　resonant　cavities　confined　with　powerful　electric　field.　Specifically,　multiple　controllable　high-quality　factor　resonances　driven　by　bound　states　in　the　continuum　(BIC)　are　realized　by　employing　longitudinal　symmetry　breaking.　The　dielectric　metamaterial　sensor　with　nearly　15.2　experimental　figure-of-merit　enabling　qualitative　and　quantitative　identification　of　different　amino　acids　by　delivering　biomolecules　to　the　hotspots　for　strong　light-matter　interactions.　It　is　envisioned　that　the　presented　strategy　will　enlighten　high-performance　meta-sensors　design　from　microwaves　to　visible　frequencies,　and　serve　as　a　potential　platform　for　microfluidic　sensing,　biomolecular　capture,　and　sorting　devices.　©　2024　Elsevier　B.V.