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author：

Xia, Y. (Xia, Y..) [1] | Tang, Y. (Tang, Y..) [2] | Huang, Z. (Huang, Z..) [3] | Ke, N. (Ke, N..) [4] | Zheng, Y. (Zheng, Y..) [5] | Zhuang, W. (Zhuang, W..) [6] | Zhang, Y. (Zhang, Y..) [7] | Yin, X. (Yin, X..) [8] | Tu, M. (Tu, M..) [9] | Chen, J. (Chen, J..) [10] | Wang, Y. (Wang, Y..) [11] | Huang, Y. (Huang, Y..) [12]

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Scopus

Abstract：

Esophageal　squamous　cell　carcinoma　(ESCC)　is　a　severe　malignancy　with　high　incidence　and　mortality　rate　in　China,　while　the　application　of　standard　chemotherapeutic　drugs　for　ESCC　meets　the　barriers　of　high　toxicity　and　multiple　drug　resistance　(MDR).　In　recent　years,　the　anticancer　effects　of　artesunate　(ART),　a　Chinese　medicine　monomer　have　gained　extensive　attentions　due　to　its　characteristics　of　low　toxicity,　high　potency,　and　reversal　of　MDR.　In　this　study,　we　develop　the　artesunate-loaded　solid　lipid　nanoparticles　(SLNART)　to　overcome　the　poor　water　solubility　and　bioavailability　of　ART,　further　improving　the　efficiency　of　ART　on　ESCC　treatment.　Especially　mentioned,　SLNART　is　shown　to　present　marked　inhibitory　effects　on　ESCC　development　based　on　the　induction　of　ferroptosis　by　two　pathways　included　upregulating　TFR　to　increase　Fe2+　ions　and　inhibiting　the　AKT/mTOR　signaling　to　downregulate　GPX4.　Collectively,　this　study　is　the　first　to　pave　a　promising　approach　for　ESCC　therapy　based　on　a　strategy　of　developing　SLNART　to　induce　ferroptosis　by　mediating　Fe2+　ions　and　AKT/mTOR　signaling.　©　2024　Elsevier　Inc.

Keyword：

AKT/mTOR signaling Artesunate ESCC Ferroptosis Solid lipid nanoparticles

Community：

  • [ 1 ] [Xia Y.]College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350000, China
  • [ 2 ] [Xia Y.]Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, 350001, China
  • [ 3 ] [Tang Y.]College of Chemical Engineering, Fuzhou University, Fuzhou, 350108, China
  • [ 4 ] [Tang Y.]Engineering Research Center of Advanced Manufacturing Technology for Fine Chemicals, College of Chemical Engineering, Fuzhou University, Fuzhou, 350108, China
  • [ 5 ] [Huang Z.]College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350000, China
  • [ 6 ] [Huang Z.]Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, 350001, China
  • [ 7 ] [Ke N.]Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China
  • [ 8 ] [Ke N.]Department of Clinical Laboratory, Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, 350001, China
  • [ 9 ] [Zheng Y.]Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, 350001, China
  • [ 10 ] [Zheng Y.]Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China
  • [ 11 ] [Zhuang W.]Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, 350001, China
  • [ 12 ] [Zhuang W.]Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China
  • [ 13 ] [Zhang Y.]Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, 350001, China
  • [ 14 ] [Zhang Y.]Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China
  • [ 15 ] [Yin X.]College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350000, China
  • [ 16 ] [Yin X.]Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, 350001, China
  • [ 17 ] [Tu M.]Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, 350001, China
  • [ 18 ] [Tu M.]Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China
  • [ 19 ] [Chen J.]Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, 350001, China
  • [ 20 ] [Chen J.]Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China
  • [ 21 ] [Wang Y.]College of Chemical Engineering, Fuzhou University, Fuzhou, 350108, China
  • [ 22 ] [Wang Y.]Engineering Research Center of Advanced Manufacturing Technology for Fine Chemicals, College of Chemical Engineering, Fuzhou University, Fuzhou, 350108, China
  • [ 23 ] [Huang Y.]College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350000, China
  • [ 24 ] [Huang Y.]Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, 350001, China
  • [ 25 ] [Huang Y.]Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China
  • [ 26 ] [Huang Y.]Central Laboratory, Center for Experimental Research in Clinical Medicine, Fujian Provincial Hospital, Fuzhou, 350001, China
  • [ 27 ] [Huang Y.]Fujian Provincial Key Laboratory of Critical Care Medicine, Fujian Provincial Key Laboratory of Cardiovascular Disease, Fuzhou, 350001, China

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Source ：

Cellular Signalling

ISSN： 0898-6568

Year： 2024

Volume： 117

4 . 4 0 0

JCR@2023

CAS Journal Grade：3

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 2

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