Conductive　hydrogels　become　increasing　attractive　for　flexible　electronic　devices　and　biosensors.　However,　challenges　still　remain　in　fabrication　of　flexible　hydrogels　with　high　electrical　conductivity,　self-healing　capability　and　adhesion　property.　Herein,　a　conductive　hydrogel　(PSDM)　was　prepared　by　solution-gel　method　using　MXene　and　dopamine　modified　polypyrrole　as　conductive　enhanced　materials,　polyvinyl　alcohol　and　silk　fibroin　as　gel　networks,　and　borax　as　cross-linking　agent.　Notably,　the　PSDM　hydrogels　not　only　showed　high　permeability　(13.82　mg∙cm−2∙h−1),　excellent　stretch　ability　(1235　%),　high　electrical　conductivity　(11.3　S/m)　and　long-term　stability,　but　also　exhibited　high　adhesion　performance　and　self-healing　properties.　PSDM　hydrogels　displayed　outstanding　sensing　performance　and　durability　for　monitoring　human　activities　including　writing,　finger　bending　and　wrist　bending.　The　PSDM　hydrogel　was　made　into　wearable　flexible　electrodes　and　realized　accurate,　sensitive　and　reliable　detection　of　human　electromyographic　and　electrocardiographic　signals.　The　sensor　was　also　applied　in　human-computer　interaction　by　collecting　electromyography　signals　of　different　gestures　for　machine　learning　and　gesture　recognition.　According　to　480　groups　of　data　collected,　the　recognition　accuracy　of　gestures　by　the　electrodes　was　close　to　100　%,　indicating　that　the　PSDM　hydrogel　electrodes　possessed　excellent　sensing　performance　for　high　precision　data　acquisition　and　human-computer　interaction　interface.　©　2024　Elsevier　B.V.