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author：

Yu, M. (Yu, M..) [1] | Ye, Z. (Ye, Z..) [2] | Liu, S. (Liu, S..) [3] | Zhu, Y. (Zhu, Y..) [4] | Niu, X. (Niu, X..) [5] | Wang, J. (Wang, J..) [6] | Ao, R. (Ao, R..) [7] | Huang, H. (Huang, H..) [8] | Cai, H. (Cai, H..) [9] | Liu, Y. (Liu, Y..) [10] | Chen, X. (Chen, X..) [11] | Lin, L. (Lin, L..) [12]

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Scopus

Abstract：

Real-time　monitoring　of　hydroxyl　radical　(⋅OH)　generation　is　crucial　for　both　the　efficacy　and　safety　of　chemodynamic　therapy　(CDT).　Although　⋅OH　probe-integrated　CDT　agents　can　track　⋅OH　production　by　themselves,　they　often　require　complicated　synthetic　procedures　and　suffer　from　self-consumption　of　⋅OH.　Here,　we　report　the　facile　fabrication　of　a　self-monitored　chemodynamic　agent　(denoted　as　Fc-CD-AuNCs)　by　incorporating　ferrocene　(Fc)　into　β-cyclodextrin　(CD)-functionalized　gold　nanoclusters　(AuNCs)　via　host–guest　molecular　recognition.　The　water-soluble　CD　served　not　only　as　a　capping　agent　to　protect　AuNCs　but　also　as　a　macrocyclic　host　to　encapsulate　and　solubilize　hydrophobic　Fc　guest　with　high　Fenton　reactivity　for　in　vivo　CDT　applications.　Importantly,　the　encapsulated　Fc　inside　CD　possessed　strong　electron-donating　ability　to　effectively　quench　the　second　near-infrared　(NIR-II)　fluorescence　of　AuNCs　through　photoinduced　electron　transfer.　After　internalization　of　Fc-CD-AuNCs　by　cancer　cells,　Fenton　reaction　between　redox-active　Fc　quencher　and　endogenous　hydrogen　peroxide　(H2O2)　caused　Fc　oxidation　and　subsequent　NIR-II　fluorescence　recovery,　which　was　accompanied　by　the　formation　of　cytotoxic　⋅OH　and　therefore　allowed　Fc-CD-AuNCs　to　in　situ　self-report　⋅OH　generation　without　undesired　⋅OH　consumption.　Such　a　NIR-II　fluorescence-monitored　CDT　enabled　the　use　of　renal-clearable　Fc-CD-AuNCs　for　efficient　tumor　growth　inhibition　with　minimal　side　effects　in　vivo.　©　2023　Wiley-VCH　GmbH.

Keyword：

Antitumor Agents Chemodynamic Therapy Ferrocene Host-Guest Systems NIR-II Fluorescence

Community：

  • [ 1 ] [Yu M.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 2 ] [Ye Z.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 3 ] [Liu S.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 4 ] [Zhu Y.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 5 ] [Zhu Y.]Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore, 117597, Singapore
  • [ 6 ] [Zhu Y.]Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore
  • [ 7 ] [Niu X.]Department of Neurosurgery, Neurosurgery Research Institute, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China
  • [ 8 ] [Wang J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 9 ] [Ao R.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 10 ] [Huang H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 11 ] [Cai H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 12 ] [Liu Y.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 13 ] [Chen X.]Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore, 117597, Singapore
  • [ 14 ] [Chen X.]Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore
  • [ 15 ] [Lin L.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China

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Source ：

Angewandte Chemie - International Edition

ISSN： 1433-7851

Year： 2024

Issue： 10

Volume： 63

1 6 . 1 0 0

JCR@2023

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WoS CC Cited Count：

SCOPUS Cited Count： 5

ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 0

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