The　absorbent　of　Fe-loaded　cellulose/bayberry　tannin　(Fe-CBT)　was　prepared　via　impregnation　and　in-situ　reduction　process,　with　cellulose/tannin　composite　aerogel　(CBT)　as　the　carrier,　which　then　was　characterized　by　means　of　scanning　electron　microscopy,　Fourier　infrared　spectroscopy　and　Х-ray　energy　dispersive　spectroscopy.　Afterwards,　the　adsorption　characteristic　of　the　Fe-CBT　was　comparatively　assessed　for　three　typical　fluoroquinolones　(FQs)　antibiotics,　i.e.,　norfloxacin　(NOR),　lomefloxacin　hydrochloride　(LOM)　and　levofloxacin　hydrochloride　(LVХ).　The　results　show　that　the　coexistence　of　cations　Na+,　K+,　Mg2+　and　Ca2+　all　interferes　significantly　with　the　adsorption　process.　Moreover,　the　adsorption　process　is　an　exothermic　reaction　that　proceeds　spontaneously,　mainly　as　single-molecule　layer　adsorption,　of　which　chemisorption　is　the　main　rate-limiting　step.　The　quasi-secondary　and　Langmuir　models　are　demonstrated　to　fit　this　adsorption　behavior,　and　the　maximum　theoretical　adsorption　capacity　of　99.07,　74.17　and　40.14　mg/g　can　be　achieved　for　NOR,　LOM　and　LVХ　at　298　K,　respectively.　Both　NaOH　and　NaCl　show　superior　elution　effect　on　Fe-CBT,　namely,　after　re-generation　for　four　times　with　NaOH　and　NaCl　solutions,　the　adsorption　capacity　of　Fe-CBT　on　NOR　could　even　be　maintained　＞　70%.　In　addition,　it　is　found　that　the　removal　of　FQs　by　Fe-CBT　is　caused　by　the　synergy　between　electrostatic　gravitation,　surface　complexation,　hydrogen　bonding　and　π-π　stacking.　©　2024　Chinese　Journal　of　Materials　Research.　All　rights　reserved.