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author:

Pan, Dawei (Pan, Dawei.) [1] | Lu, Ping (Lu, Ping.) [2] | Wu, Yunbing (Wu, Yunbing.) [3] (Scholars:吴运兵) | Kang, Liping (Kang, Liping.) [4] | Huang, Fengxin (Huang, Fengxin.) [5] | Lin, Kaibiao (Lin, Kaibiao.) [6] | Yang, Fan (Yang, Fan.) [7]

Indexed by:

Scopus SCIE

Abstract:

Potential drug-drug interactions (DDI) can lead to adverse drug reactions (ADR), and DDI prediction can help pharmacy researchers detect harmful DDI early. However, existing DDI prediction methods fall short in fully capturing drug information. They typically employ a single-view input, focusing solely on drug features or drug networks. Moreover, they rely exclusively on the final model layer for predictions, overlooking the nuanced information present across various network layers. To address these limitations, we propose a multi-scale dual-view fusion (MSDF) method for DDI prediction. More specifically, MSDF first constructs two views, topological and feature views of drugs, as model inputs. Then a graph convolutional neural network is used to extract the feature representations from each view. On top of that, a multi-scale fusion module integrates information across different graph convolutional layers to create comprehensive drug embeddings. The embeddings from the two views are summed as the final representation for classification. Experiments on two real-world datasets demonstrate that MSDF achieves higher accuracy than state-of-the-art methods, as the dual-view, multi-scale approach better captures drug characteristics.

Keyword:

drug drug interaction prediction graph features represent learning graph neural network multi-class classification multi-scale fusion

Community:

  • [ 1 ] [Pan, Dawei]Xiamen Univ Technol, Sch Comp & Informat Engn, Xiamen, Peoples R China
  • [ 2 ] [Huang, Fengxin]Xiamen Univ Technol, Sch Comp & Informat Engn, Xiamen, Peoples R China
  • [ 3 ] [Lin, Kaibiao]Xiamen Univ Technol, Sch Comp & Informat Engn, Xiamen, Peoples R China
  • [ 4 ] [Lu, Ping]Xiamen Univ Technol, Sch Econ & Management, Xiamen, Peoples R China
  • [ 5 ] [Wu, Yunbing]Fuzhou Univ, Coll Comp & Big Data, Fuzhou, Peoples R China
  • [ 6 ] [Kang, Liping]Soochow Univ, Pasteur Inst, Suzhou, Peoples R China
  • [ 7 ] [Yang, Fan]Xiamen Univ, Shenzhen Res Inst, Shenzhen, Peoples R China
  • [ 8 ] [Yang, Fan]Xiamen Univ, Dept Automat, Xiamen, Peoples R China

Reprint 's Address:

  • 吴运兵

    [Lu, Ping]Xiamen Univ Technol, Sch Econ & Management, Xiamen, Peoples R China;;[Wu, Yunbing]Fuzhou Univ, Coll Comp & Big Data, Fuzhou, Peoples R China;;[Yang, Fan]Xiamen Univ, Shenzhen Res Inst, Shenzhen, Peoples R China;;[Yang, Fan]Xiamen Univ, Dept Automat, Xiamen, Peoples R China

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Source :

FRONTIERS IN PHARMACOLOGY

ISSN: 1663-9812

Year: 2024

Volume: 15

4 . 4 0 0

JCR@2023

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

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