Li-rich　Mn-based　materials　(LRMs)　with　high　energy　density　are　promising　cathode　candidates　for　next-generation　lithium-ion　batteries.　However,　the　inevitable　oxygen　release　and　electrolyte　decomposition　would　stimulate　successive　interface　side　reactions　and　structure　degradation,　leading　to　rapid　capacity　decay.　In　addition,　the　terrible　reaction　kinetics　of　LRMs　is　not　conducive　to　rate　capability　and　low-temperature　performance.　Herein,　a　multi-functionalized　full-interface　integrated　engineering　is　put　forward　to　introduce　multifunctional　modification　layer　(including　surface　S,　N　co-doped　carbon　layer,　near-surface　gradient　oxygen　vacancies　and　the　resultantly　induced　atomic　rearrangement)　at　the　interface　of　both　the　secondary　particles　and　inner　primary　particles　of　LRMs.　The　oxygen　vacancies　and　induced　intralayer　Li/Mn　disorder　can　suppress　the　oxygen　release.　And　the　induced　lattice-matched　rock-salt　phase　can　improve　the　interface　structure　stability.　Meanwhile,　the　S,　N　co-doped　carbon　layer　can　isolate　LRMs　and　electrolyte,　alleviating　the　decomposition　of　electrolyte　and　the　resulting　structural　damage　to　LRMs.　In　addition,　Li+　diffusion　kinetic　and　electric　conductivity　are　enhanced　due　to　oxygen　vacancies　and　S,　N　co-doped　carbon　layer.　Thus,　a　reliable　LiF-rich　cathode　electrolyte　interphase　(CEI)　film　is　formed,　which　can　further　reduce　the　interfacial　side　reactions　upon　cycling,　ultimately　enhancing　the　comprehensive　electrochemical　performance　of　LRMs.　Specifically,　the　modified　sample　(HLRM)　exhibits　enhanced　long-term　cycle　stability,　with　capacity　retention　of　94.8　%　and　86.6　%　after　100　cycles　at　0.2　C　and　500　cycles　at　1　C,　respectively.　In　addition,　HLRM　delivers　elevated　specific　capacity　and　cyclic　stability　both　at　high　(55　degrees　C)　and　low　(-15　degrees　C)　temperature.　This　work　offers　a　new　idea　to　improve　the　comprehensive　electrochemical　performance　of　LRMs　by　multi-functionalized　full-interface　integrated　modification　engineering.