High-salinity　textile　wastewater　is　a　pressing　environmental　concern,　urgently　requiring　the　appropriate　treatment.　Sustainable　management　of　high-salinity　textile　wastewater　via　fractionation　of　the　existing　dyes　and　inorganic　salts　(NaCl)　using　selective　separation　membranes　is　a　key　approach　to　address　this　detrimental　concern.　Herein,　tight　composite　ultrafiltration　membranes　with　impressive　antibacterial　function　were　constructed　using　one-step　co-deposition　of　dopamine　and　tobramycin　on　the　porous　substrate　to　fractionate　the　dyes　and　NaCl.　Triggered　by　ammonia　persulfate,　the　polydopamine/tobramycin　coating　layer　imparts　the　fabricated　composite　ultrafiltration　membranes　with　tight　surface　structure　and　narrow　pore　size　distribution,　enabling　effective　dyes/salts　fractionation.　Specifically,　the　tight　composite　ultrafiltration　membrane　with　a　molecular　weight　cutoff　of　3692　Da　experienced　a　＞　98.0　%　rejection　against　various　reactive　dyes　(molecular　weight:　＜1000　Da)　with　nearly　complete　salt　transmission　(＜0.8　%　NaCl　rejection),　demonstrating　an　effective　fractionation　of　dyes　and　salts.　Additionally,　the　incorporated　tobramycin　as　a　broad-spectrum　antibiotic　endowed　the　tight　composite　ultrafiltration　membrane　with　a　sufficient　inhibition　efficiency　(i.e.,　100　%)　against　E.　coli　bacteria　in　a　short-time　contact　(i.e.,　3　min).　Thereby,　the　tight　composite　ultrafiltration　membrane　constructed　by　fast　co-deposition　of　dopamine　and　tobramycin　established　an　unparalleled　platform　technology　for　sustainable　resource　recovery　(dyes　or　salts)　from　high-salinity　textile　wastewater.