Objective:　We　analyzed　adult　ADHD　symptoms　in　a　cross-cultural　context,　including　investigating　the　occurrence　and　potential　correlates　of　adult　ADHD　and　psychometric　examination　of　the　Adult　ADHD　Self-Report　Scale　(ASRS)　Screener.　Method:　Our　analysis　is　based　on　a　large-scale　research　project　involving　42　countries　(International　Sex　Survey,　N=72,627,　57%　women,　Mage=32.84;　SDage=12.57).　Results:　The　ASRS　Screener　demonstrated　good　reliability　and　validity,　along　with　partial　invariance　across　different　languages,　countries,　and　genders.　The　occurrence　of　being　at　risk　for　adult　ADHD　was　relatively　high　(21.4%　for　women,　18.1%　for　men).　The　highest　scores　were　obtained　in　the　US,　Canada,　and　other　English-speaking　Western　countries,　with　significantly　lower　scores　among　East　Asian　and　non-English-speaking　European　countries.　Moreover,　ADHD　symptom　severity　and　occurrence　were　especially　high　among　gender-diverse　individuals.　Significant　associations　between　adult　ADHD　symptoms　and　age,　mental　and　sexual　health,　and　socioeconomic　status　were　observed.　Conclusions:　Present　results　show　significant　cross-cultural　variability　in　adult　ADHD　occurrence　as　well　as　highlight　important　factors　related　to　adult　ADHD.　Moreover,　the　importance　of　further　research　on　adult　ADHD　in　previously　understudied　populations　(non-Western　countries)　and　minority　groups　(gender-diverse　individuals)　is　stressed.　Lastly,　the　present　analysis　is　consistent　with　previous　evidence　showing　low　specificity　of　adult　ADHD　screening　instruments　and　contributes　to　the　current　discussion　on　accurate　adult　ADHD　screening　and　diagnosis.