Covalent　organic　framework　(COF)-based　membranes　are　burgeoning　candidates　for　separation　technologies　owing　to　their　well-ordered　channel　structures.　However,　it　is　still　a　significant　challenge　to　obtain　high-quality　COF　membranes　with　a　mild　and　convenient　preparation　strategy.　In　this　paper,　we　adopted　a　simple　liquid-liquid　interfacial　polymerization　method　to　manufacture　a　self-standing　COF　membrane　with　decent　crystallinity　at　room　temperature.　Aldehyde　monomer　and　catalyst　were　dissolved　in　water　as　the　bottom　layer　and　the　amine　monomer　was　dissolved　in　ethyl　acetate　as　the　top　layer,　and　new　COF　membranes　were　subsequently　obtained　by　interfacial　polymerization　in　the　two-phase　interface.　The　synthetic　conditions　including　precursor　and　catalyst　dosage　were　further　optimized,　and　thus-synthesized　PDA-TAPB-ABC　membrane　displayed　a　stable　rejection　to　MB　of　97.57%　with　a　high　water　permeance　of　up　to　101.　32　L　m−2h−1bar−1.　Its　dyes　separation　performance　was　much　better　than　their　AA-stacking　counterpart.　Moreover,　the　prepared　membrane　endowed　favorable　chemical　stability　and　long-term　durability.　©　2024　Elsevier　Ltd