Piezo-catalysis　is　a　green　and　effective　method　for　degrading　rich　and　obstinate　molecules　in　wastewater.　Yet,　the　piezo-catalytic　performance　of　frequently-used　barium　titanate　(BTO)　is　still　limited　for　practical　applications,　thus　it　is　crucial　to　construct　high-efficiency　BTO-based　catalysts.　Herein,　BiOBr/BTO　heterojunction-based　piezo-photocatalysts　were　successfully　prepared　using　the　chemical　precipitation　method,　and　an　internal　electric　field　was　established　via　ultrasound　to　promote　the　separation　of　photogenerated　electron-hole　pairs　through　the　synergistic　effect　of　piezocatalysis　and　photocatalysis.　Transmission　electron　microscopy,　Raman　spectroscopy　and　X-ray　photoelectron　spectroscopy　were　utilized　to　characterize　the　heterojunction.　The　degradation　performance　of　Rhodamine　B　(RhB)　by　BiOBr/BTO　is　the　best　among　various　pollutants,　giving　a　reaction　rate　constant　up　to　20.839　×　10−2　min−1,　exceeding　numerous　previously　reported　catalysts.　In　addition,　the　piezo-photocatalytic　reaction　rate　of　BiOBr/BTO　for　Methyl　Orange　was　9.298　×　10−2　min−1,　≈　3.3　times　than　those　of　pure　BTO　(2.806　×　10−2　min−1),　and　also　≈　15.9　times　and　3.3　times　than　those　of　single　photocatalysis　(0.585　×　10−2　min−1)　or　piezocatalysis　(2.848　×　10−2　min−1).　Importantly,　the　BiOBr/BTO　heterojunction　demonstrates　excellent　catalytic　degradation　performance　for　a　broad　range　of　pollutants　(e.g.,　dyes　and　antibiotics)　and　their　mixtures,　as　well　as　favorable　cycling　stability　and　repeatability　with　changed　environmental　conditions,　displaying　applicability　in　actual　wastewater　treatment.　The　possible　degradation　pathways　of　RhB　were　analyzed　by　liquid　chromatography-mass　spectrometry.　The　present　work　supplies　a　feasible　strategy　for　the　preparation　of　high-efficiency　piezo-photocatalytic　BTO-based　heterojunctions,　which　can　guide　other　composites　for　environmental　remediation.　©　2024　Elsevier　B.V.