'Three-key-and-lock' near-infrared fluorescent probe for dual-channel tracking ONOO− in mitochondria and viscosity in lysosomes in ferroptosis and drug-induced liver injury - Details

author：

Liu, Yunfan (Liu, Yunfan.) ^[1] | Wang, Xuyan (Wang, Xuyan.) ^[2] | Fu, Nanyan (Fu, Nanyan.) ^[3] | Wang, Guimei (Wang, Guimei.) ^[4]

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Abstract：

The　processes　of　ferroptosis　and　drug-induced　liver　injury　(DILI)　correlate　closely　to　oxidative　stress　in　mitochondria　which　will　affect　intracellular　microenvironmental　parameters　such　as　lysosomal　viscosity.　Therefore,　it　is　of　great　significance　to　dynamically　monitor　ONOO−　in　mitochondria　and　viscosity　in　lysosomes　for　understanding　redox　signal　transduction　but　remains　challenging.　Here　we　report　a　near-infrared　fluorescent　probe,　HCy-OH-mito,　which　has　the　dual-organelle　targeting　ability　for　the　detection　of　ONOO−　in　mitochondria　and　viscosity　in　lysosomes　via　a　＇three-key-and-lock＇　strategy.　HCy-OH-mito　has　been　successfully　applied　to　independently　and　simultaneously　label　mitochondria　and　lysosomes　in　live　cells,　and　monitor　the　fluctuations　of　ONOO−　in　mitochondria　and　viscosity　in　lysosomes　during　ferroptosis　and　APAP-induced　liver　injury　and　in　live　zebrafish.　©　2024　Elsevier　Ltd

Keyword：

Diseases Fluorescence Fluorescence spectroscopy Infrared devices Locks (fasteners) Mitochondria Probes Signal transduction Viscosity

Community：

[ 1 ] [Liu, Yunfan]Laboratory of Analytical Science for Food Safety and Biology (MOE & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 2 ] [Wang, Xuyan]Laboratory of Analytical Science for Food Safety and Biology (MOE & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 3 ] [Fu, Nanyan]Laboratory of Analytical Science for Food Safety and Biology (MOE & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 4 ] [Wang, Guimei]Laboratory of Analytical Science for Food Safety and Biology (MOE & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou; 350108, China

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Source ：

Dyes and Pigments

ISSN： 0143-7208

Year： 2024

Volume： 225

4 . 1 0 0

JCR@2023

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 3

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