In　recent　studies,　carbon　nanotube　(CNTs)　materials　and　their　composites　have　demonstrated　remarkable　catalytic　activity　in　the　activation　of　persulfate　(PS),　facilitating　the　efficient　degradation　of　organic　pollutants.　In　this　study,　a　novel　Co　loaded　carbon　nanotubes　(CoO@CNT)　catalyst　was　prepared　to　promote　PDS　activation　for　the　degradation　of　sulfafurazole　(SIZ).　Experimental　results,　the　CNT　as　a　carrier　effectively　reduces　the　leaching　of　cobalt　ions　and　improves　the　electron　transport　capacity　,whereas　the　introduced　Co　effectively　activates　the　PDS,　promoting　the　generation　of　highly　reactive　radicals　to　degrade　SIZ.　Under　optimized　conditions　(a　catalyst　dose　of　0.2　g/L,　a　PDS　dose　of　1　g/L　and　an　initial　pH　=　9.0),　the　obtained　CoO@CNT　demonstrated　favorable　Fenton-like　performance,　reaching　a　degradation　efficiency　of　95.55%　within　30　min.　Furthermore,　density　functional　theory　(DFT)　calculations　demonstrate　that　the　introduction　of　cobalt　(Co)　accelerates　electron　transfer,　promoting　the　decomposition　of　PDS　while　facilitating　the　Co　2　+　/Co　3　+　redox　cycling.　We　further　employed　the　environmental　chemistry　and　risk　assessment　system　(ECOSAR)　to　evaluate　the　ecological　toxicity　of　intermediate　products,　revealing　a　significant　reduction　in　ecological　toxicity　associated　with　this　degradation　process,　thereby　confirming　its　environmental　harmlessness.　Through　batch　experiments　and　studies,　we　gained　a　comprehensive　understanding　of　the　mechanism　and　influencing　factors　of　CoO@CNT　in　the　role　of　SIZ　degradation,　and　provided　robust　support　for　evaluating　the　ecological　toxicity　of　degradation　products.　This　study　provides　a　significant　strategy　for　the　development　of　efficient　catalysts　incorporating　Co　for　the　environmentally　friendly　degradation　of　organic　pollutants.