Carcinoembryonic　antigen　(CEA)　is　the　most　widely　adopted　biomarker　for　the　early　determination　of　various　cancers,　thus　it　is　very　important　to　design　a　simple　and　highly　effective　sensing　method　to　detect　CEA.　Herein,　by　synthesizing　Fe-MOF　nanohybrid　loaded　with　platinum　nanoparticles　(Pt　NPs/Fe-MOF)　nanozyme　and　selecting　CEA　aptamer　(Apt)　as　the　specific　recognition　element,　a　simple　nanozyme-based　voltammetric　sensor　was　designed　to　detect　CEA　based　on　Apt-controlled　the　catalytic　activity　of　Pt　NPs/Fe-MOF　nanozyme.　The　as-synthesized　Pt　NPs/Fe-MOF　nanozyme　could　catalyze　effectively　1,2-diaminobenzene　oxidation　to　produce　electroactive　2,3-diaminophenazinc　(DAP)　which　can　exhibit　a　strong　reduction　current.　Nonetheless,　when　Pt　NPs/Fe-MOF　is　covered　fully　by　Apt　of　CEA,　the　peroxidase　activity　of　the　as-synthesized　Pt　NPs/Fe-MOF　nanozyme　is　remarkably　restricted　and　the　peak　current　of　DAP　would　disappear　nearly.　Interestingly,　this　catalytic　activity　could　be　recovered　effectively　in　the　presence　of　CEA　owing　to　the　specific　identification　of　Apt　toward　CEA.　Through　optimizing　several　experimental　factors,　the　as-designed　nanozyme　voltammetric　sensor　offers　superior　detective　performance　for　CEA.　In　addition,　the　as-designed　sensor　possesses　superior　specificity　and　selectivity,　reproducibility　and　stability　as　well　as　practical　applications,　showing　great　potentials　for　achieving　simple,　sensitive　and　highly　effective　determination　of　CEA.　©　2024　Elsevier　B.V.