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author：

Qiu, L. (Qiu, L..) [1] | Ji, H. (Ji, H..) [2] | Wang, K. (Wang, K..) [3] | Liu, W. (Liu, W..) [4] | Huang, Q. (Huang, Q..) [5] | Pan, X. (Pan, X..) [6] | Ye, H. (Ye, H..) [7] | Li, Z. (Li, Z..) [8] | Chen, G. (Chen, G..) [9] | Xing, X. (Xing, X..) [10] | Dong, X. (Dong, X..) [11] | Tang, R. (Tang, R..) [12] | Xu, H. (Xu, H..) [13] | Liu, J. (Liu, J..) [14] | Cai, Z. (Cai, Z..) [15] | Liu, X. (Liu, X..) [16]

Indexed by：

Scopus

Abstract：

Radiotherapy　(RT)　has　been　reported　to　induce　abscopal　effect　in　advanced　hepatocellular　carcinoma　(HCC),　but　such　phenomenon　was　only　observed　in　sporadic　cases.　Here,　we　demonstrated　that　subcutaneous　administration　of　Toll-like　receptor　3　(TLR3)　agonist　poly(I:C)　could　strengthen　the　abscopal　effect　during　RT　through　activating　tumor　cell　ferroptosis　signals　in　bilateral　HCC　subcutaneous　tumor　mouse　models,　which　could　be　significantly　abolished　by　TLR3　knock-out　or　ferroptosis　inhibitor　ferrostatin-1.　Moreover,　poly(I:C)　could　promote　the　presentation　of　tumor　neoantigens　by　dendritic　cells　to　enhance　the　recruitment　of　activated　CD8+　T　cells　into　distant　tumor　tissues　for　inducing　tumor　cell　ferroptosis　during　RT　treatment.　Finally,　the　safety　and　feasibility　of　combining　poly(I:C)　with　RT　for　treating　advanced　HCC　patients　were　further　verified　in　a　prospective　clinical　trial.　Thus,　enhancing　TLR3　signaling　activation　during　RT　could　provide　a　novel　strategy　for　strengthening　abscopal　effect　to　improve　the　clinical　benefits　of　advanced　HCC　patients.　©　The　Author(s)　2024.

Keyword：

Abscopal Effect Ferroptosis Hepatocellular Carcinoma Poly(I:C) Radiotherapy

Community：

  • [ 1 ] [Qiu L.]College of Chemical Engineering, Fuzhou University, Fuzhou, China
  • [ 2 ] [Qiu L.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China
  • [ 3 ] [Qiu L.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, China
  • [ 4 ] [Qiu L.]Mengchao Med-X Center, Fuzhou University, Fuzhou, China
  • [ 5 ] [Ji H.]Radiotherapy Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China
  • [ 6 ] [Wang K.]Radiotherapy Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China
  • [ 7 ] [Liu W.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China
  • [ 8 ] [Huang Q.]Radiotherapy Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China
  • [ 9 ] [Pan X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China
  • [ 10 ] [Pan X.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, China
  • [ 11 ] [Pan X.]Mengchao Med-X Center, Fuzhou University, Fuzhou, China
  • [ 12 ] [Ye H.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China
  • [ 13 ] [Li Z.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China
  • [ 14 ] [Li Z.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, China
  • [ 15 ] [Li Z.]Mengchao Med-X Center, Fuzhou University, Fuzhou, China
  • [ 16 ] [Chen G.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China
  • [ 17 ] [Chen G.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, China
  • [ 18 ] [Chen G.]Mengchao Med-X Center, Fuzhou University, Fuzhou, China
  • [ 19 ] [Xing X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China
  • [ 20 ] [Xing X.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, China
  • [ 21 ] [Xing X.]Mengchao Med-X Center, Fuzhou University, Fuzhou, China
  • [ 22 ] [Dong X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China
  • [ 23 ] [Dong X.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, China
  • [ 24 ] [Dong X.]Mengchao Med-X Center, Fuzhou University, Fuzhou, China
  • [ 25 ] [Tang R.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China
  • [ 26 ] [Tang R.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, China
  • [ 27 ] [Tang R.]Mengchao Med-X Center, Fuzhou University, Fuzhou, China
  • [ 28 ] [Xu H.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China
  • [ 29 ] [Xu H.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, China
  • [ 30 ] [Xu H.]Mengchao Med-X Center, Fuzhou University, Fuzhou, China
  • [ 31 ] [Liu J.]College of Chemical Engineering, Fuzhou University, Fuzhou, China
  • [ 32 ] [Cai Z.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China
  • [ 33 ] [Cai Z.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, China
  • [ 34 ] [Cai Z.]Mengchao Med-X Center, Fuzhou University, Fuzhou, China
  • [ 35 ] [Liu X.]College of Chemical Engineering, Fuzhou University, Fuzhou, China
  • [ 36 ] [Liu X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China
  • [ 37 ] [Liu X.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, China
  • [ 38 ] [Liu X.]Mengchao Med-X Center, Fuzhou University, Fuzhou, China

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Source ：

EMBO Molecular Medicine

ISSN： 1757-4676

Year： 2024

Issue： 5

Volume： 16

Page： 1193-1219

9 . 0 0 0

JCR@2023

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 3

ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 0

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