Preventive Effect of Lactobacillus paracasei FZU103 on Alcoholic Liver Injury in Mice - Details

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Abstract：

Objective:　To　explore　the　preventive　effect　of　Lactobacillus　paracasei　FZU103　(LP-FZU103)　on　alcoholic　liver　injury　(ALI).　Methods:　Altogether　36　specific　pathogen　free-　(SPF-)　grade　ICR　mice　were　randomly　divided　into　three　groups:　control,　model　and　experimental　(LP-FZU103　intervention).　After　the　six-week　experiment,　body　mass,　organ　coefficients,　serum　and　liver　biochemical　indexes,　liver　histopathology　and　inflammatory　cytokines,　the　transcription　of　liver　function-related　genes　and　intestinal　flora　composition　were　measured.　Results:　Compared　with　the　model　group,　intervention　of　LP-FZU103　improved　the　organ　coefficients　and　pathological　liver　damage　in　ALI　mice,　significantly　reduced　the　levels　of　total　cholesterol　(TC),　triglyceride　(TG)　and　low-density　lipoprotein　cholesterol　(LDL-C)　as　well　as　the　activity　of　alanine　aminotransferase　(ALT)　and　aspartate　aminotransferase　(AST)　in　the　serum,　increased　the　serum　concentration　of　high-density　lipoprotein　cholesterol　(HDL-C),　significantly　increased　the　activity　of　catalase　(CAT)　and　superoxide　dismutase　(SOD)　and　the　content　of　glutathione　(GSH)　in　the　liver,　and　decreased　MDA　content　and　interleukin-6　(IL-6),　interferon-γ　(IFN-γ)　levels　in　the　liver.　Moreover,　LP-FZU103　intervention　significantly　up-regulated　the　mRNA　expression　level　of　the　lipid　metabolism-related　gene　Ldlr　and　down-regulated　the　mRNA　expression　level　of　Acc1,　Hmgcr　and　Cd36　as　well　as　increased　the　relative　abundance　of　beneficial　bacteria　such　as　Lactobacillus　johnsonii,　Lactobacillus　reuteri　and　Lactobacillus　paracasei　in　the　gut　of　mice.　Conclusion:　LP-FZU103　intervention　can　prevent　and　control　the　occurrence　of　alcoholic　liver　injury　in　mice,　which　is　closely　related　to　the　improved　intestinal　flora　and　liver　metabolic　function.　©　2024　Chinese　Chamber　of　Commerce.　All　rights　reserved.

Keyword：

Amino acids Cholesterol Diseases Lipoproteins Mammals Metabolism Superoxide dismutase Transcription Urea

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[ 1 ] [Liang, Zihua]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou; 350108, China
[ 2 ] [Liang, Zihua]Food Nutrition and Health Research Center, School of Advanced Manufacturing, Fuzhou University, Jinjiang; 362200, China
[ 3 ] [Li, Jiayi]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou; 350108, China
[ 4 ] [Li, Jiayi]Food Nutrition and Health Research Center, School of Advanced Manufacturing, Fuzhou University, Jinjiang; 362200, China
[ 5 ] [Xie, Linhui]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou; 350108, China
[ 6 ] [Yang, Ziyi]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou; 350108, China
[ 7 ] [Yang, Ziyi]Food Nutrition and Health Research Center, School of Advanced Manufacturing, Fuzhou University, Jinjiang; 362200, China
[ 8 ] [You, Shize]The First Clinical Medical College, Fujian Medical University, Fuzhou; 350004, China
[ 9 ] [Wu, Chao]The First Clinical Medical College, Fujian Medical University, Fuzhou; 350004, China
[ 10 ] [Li, Wenlong]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou; 350108, China
[ 11 ] [Li, Wenlong]Food Nutrition and Health Research Center, School of Advanced Manufacturing, Fuzhou University, Jinjiang; 362200, China
[ 12 ] [Ai, Lianzhong]Shanghai Engineering Research Center of Food Microbiology, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai; 200093, China
[ 13 ] [Ni, Li]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou; 350108, China
[ 14 ] [Ni, Li]Food Nutrition and Health Research Center, School of Advanced Manufacturing, Fuzhou University, Jinjiang; 362200, China
[ 15 ] [Lü, Xucong]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou; 350108, China
[ 16 ] [Lü, Xucong]Food Nutrition and Health Research Center, School of Advanced Manufacturing, Fuzhou University, Jinjiang; 362200, China
[ 17 ] [Chen, Youting]Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Fujian Medical University, Fuzhou; 350004, China