Achieving　a　delicate　equilibrium　between　the　mechanical　and　antifouling　attributes　of　silicone-based　coatings　remains　a　formidable　task.　This　research　unveiled　a　novel　approach　to　crafting　a　hybrid　antifouling　coating　through　the　amalgamation　of　an　amphiphilic　telomer,　Zirconia　(ZrO2)　sol,　triethoxyoctylsilane　(KH832)　and　tetraethyl　orthosilicate　(TEOS)　using　an　uncomplicated　sol–gel　technique.　The　amphiphilic　telomer,　derived　from　a　synthesized　antibacterial　acrylamide-benzothiazole　small　molecule,　hydrophobic　silanes/fluorosilanes,　and　hydrophilic　monomers,　was　intricately　tethered　with　the　ZrO2　sol,　synthesized　through　the　hydrolysis　of　n-propyl　zirconate.　The　resultant　coating　achieved　exceptional　transparency　(＞98　%　transmittance),　attributed　to　the　covalent　linkage　between　the　robust　zirconia　structure　and　the　pliable,　long-chain　telomer.　This　unique　bonding　imparted　the　coating　with　remarkable　characteristics,　including　high　hardness　(4–6H),　flexibility　(∼5　mm　bending　diameter),　wear　resistance,　and　strong　adhesion　(∼2.89　MPa)　to　the　substrate.　Furthermore,　the　self-enrichment　property　of　the　non-leaching　amphiphilic　telomer　within　the　hybrid　matrix　contributed　to　the　coating＇s　outstanding　self-cleaning　capabilities,　as　well　as　its　remarkable　ability　to　resist　fouling,　including　bacterial　adhesion,　protein　attachment,　diatom　deposition,　and　biofilm　formation.　Overall,　our　research　systematically　explored　the　influence　of　composition　and　structure　on　both　mechanical　properties　and　antifouling　performance.　Ultimately,　we　sought　to　advance　the　development　of　a　high-performance　organic–inorganic　hybrid　antifouling　coating　poised　to　address　the　diverse　requirements　of　applications　spanning　optical　instruments,　foldable　displays,　marine　facilities,　and　various　other　fields.　©　2024