The　management　of　severe　full-thickness　skin　defect　wounds　remains　a　challenge　due　to　their　irregular　shape,　uncontrollable　bleeding,　high　risk　of　infection,　and　prolonged　healing　period.　Herein,　an　all-in-one　OD/GM/QCS@Exo　hydrogel　was　prepared　with　catechol-modified　oxidized　hyaluronic　acid　(OD),　methylacrylylated　gelatin　(GM),　and　quaternized　chitosan　(QCS)　and　loaded　with　adipose　mesenchymal　stem　cell-derived　exosomes　(Exos).　Cross-linking　of　the　hydrogel　was　achieved　using　visible　light　instead　of　ultraviolet　light　irradiation,　providing　injectability　and　good　biocompatibility.　Notably,　the　incorporation　of　catechol　groups　and　multicross-linked　networks　in　the　hydrogels　conferred　strong　adhesion　properties　and　mechanical　strength　against　external　forces　such　as　tensile　and　compressive　stress.　Furthermore,　our　hydrogel　exhibited　antibacterial,　anti-inflammatory,　and　antioxidant　properties　along　with　wound-healing　promotion　effects.　Our　results　demonstrated　that　the　hydrogel-mediated　release　of　Exos　significantly　promotes　cellular　proliferation,　migration,　and　angiogenesis,　thereby　accelerating　skin　structure　reconstruction　and　functional　recovery　during　the　wound-healing　process.　Overall,　the　all-in-one　OD/GM/QCS@Exo　hydrogel　provided　a　promising　therapeutic　strategy　for　the　treatment　of　full-thickness　skin　defect　wounds　through　actively　participating　in　the　entire　process　of　wound　healing.　©　2024　American　Chemical　Society