The　seismic　fragility　of　prefabricated　self-centering　frame　structures　composed　of　self-centering　joints　is　investigated　for　reference　in　their　seismic　design　and　application.　In　this　paper,　a　new　design　of　the　concrete-filled　double　steel　tubular　column-RC　beam　joint　with　self-centering　capability　and　friction　energy　dissipation　was　proposed.　The　joint　was　modeled　with　ABAQUS　and　OpenSees,　and　hysteretic　simulation　was　carried　out　to　verify　the　reasonableness　and　accuracy　of　the　OpenSees　phenomenological　model.　Based　on　the　OpenSees　platform,　a　one-bay,　six-story　prefabricated　self-centering　frame　structure　was　modeled,　and　seismic　fragility　analysis　based　on　the　incremental　dynamic　analysis　was　performed,　in　which　seismic　fragility　curves　were　obtained　according　to　the　probabilistic　demand　analysis　model.　The　results　indicated　a　high　coincidence　in　hysteretic　curves　between　the　ABAQUS　model　and　the　OpenSees　phenomenological　model,　which　showed　favorable　self-centering　and　energy　dissipation　performance　of　the　joint　proposed　in　this　paper.　Based　on　FEMA　356,　three　kinds　of　performance　points　were　defined,　i.e.,　“Immediate　Occupancy”　(IO),　“Life　Safety”　(LS),　and　“Collapse　Prevention”　(CP).　The　prefabricated　self-centering　frame　in　this　paper　tended　to　exceed　the　IO,　where　the　stiffness　and　strength　of　the　structure　was　susceptible　to　damage.　However,　the　failure　probability　at　the　LS　performance　level　remained　low,　with　only　5%　and　37%　failure　probability　under　moderate　and　rare　earthquakes,　respectively.　The　structure　achieved　a　collapse　margin　ratio　of　4.28,　which　indicated　a　high　collapse　resistance　in　it.　©　2023