Background:　Metabolic　diseases　contribute　significantly　to　premature　mortality　worldwide,　with　increasing　burdens　observed　among　the　working-age　population　(WAP).　This　study　assessed　global,　regional,　and　national　trends　in　metabolic　disorders　and　associated　mortality　over　three　decades　in　WAP.　Methods:　Data　from　the　Global　Burden　of　Disease　2019　study　were　leveraged　to　assess　global　metabolism-associated　mortality　and　six　key　metabolic　risk　factors　in　WAP　from　1990-2019.　An　age-period-cohort　model　was　employed　to　determine　the　overall　percentage　change　in　mortality.　Results:　The　2019　global　metabolic　risk-related　mortality　rate　in　WAP　rose　significantly　by　50.73%,　while　the　age-standardized　mortality　rate　declined　by　21.5%.　India,　China,　Indonesia,　the　USA,　and　the　Russian　Federation　were　the　top　contributing　countries　to　mortality　in　WAP,　accounting　for　51.01%　of　the　total.　High　systolic　blood　pressure　(HSBP),　high　body　mass　index　(HBMI),　and　high　fasting　plasma　glucose　(HFPG)　were　the　top　metabolic　risk　factors　for　the　highest　mortality　rates.　Adverse　trends　in　HBMI-associated　mortality　were　observed,　particularly　in　lower　sociodemographic　index　(SDI)　regions.　HFPG-related　mortality　declined　globally　but　increased　in　older　age　groups　in　lower　SDI　countries.　Conclusions:　Despite　a　general　decline　in　metabolic　risk-related　deaths　in　WAP,　increasing　HBMI-　and　HFPG-related　mortality　in　lower　SDI　areas　poses　ongoing　public　health　challenges.　Developing　nations　should　prioritize　interventions　addressing　HBMI　and　HFPG　to　mitigate　mortality　risks　in　WAP.　©　2024