The　PtIn　nanoalloys　with　high　surface　energy　are　generally　in　a　metastable　state　during　harsh　reaction　conditions,　and　the　ordered　alloy　structure　is　not　conducive　to　exposure　of　surface　Pt　active　sites.　Herein,　a　strategy　for　restructuring　the　unfavorable　PtIn　alloy　structure　via　heteroatom　(Ce)　doping　is　applied　to　advance　an　isolated　Ptδ+　confined　by　the　InCeOx　nanoislands　supported　on　SiO2.　The　as-synthesized　catalyst　with　optimizing　PtIn(Ce)　ternary　components　exhibits　∼92.2%　selectivity　toward　propylene　and　a　stable　propane　conversion　of　∼67.1%　at　550　°C　(kd　of　0.010　h-1).　As　demonstrated　by　the　comprehensive　characterizations,　the　introduced　proper　amount　of　Ce　species　leads　to　the　reorganization　of　the　disadvantaged　PtIn　nanoalloy　structure　into　the　robustness　of　the　isolated　Ptδ+　site　confined　by　the　InCeOx　nanoislands　via　inhibiting　the　In0　species　generation.　The　introduced　Ce　species　modulate　the　electronic　interaction　between　Pt,　In,　and　carrier,　stimulating　the　capability　to　activate　reactive　molecules　and　at　the　same　time　acting　as　spatial　physical　barriers　to　restrict　the　migration　of　the　isolated　Ptδ+　species.　This　work　proposed　a　facile　and　efficient　strategy　to　promote　the　capability　against　sintering　and　coking　of　the　Pt-based　catalyst　in　propane　dehydrogenation.　©　2024　American　Chemical　Society.