Iron gallic acid biomimetic nanoparticles for targeted magnetic resonance imaging - Details

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Developing　T1-weighted　magnetic　resonance　imaging　(MRI)　contrast　agents　with　enhanced　biocompatibility　and　targeting　capabilities　is　crucial　owing　to　concerns　over　current　agents’　potential　toxicity　and　suboptimal　performance.　Drawing　inspiration　from　“biomimetic　camouflage,”　we　isolated　cell　membranes　(CMs)　from　human　glioblastoma　(T98G)　cell　lines　via　the　extrusion　method　to　facilitate　homotypic　glioma　targeting.　At　an　8:1　mass　ratio　of　ferric　chloride　hexahydrate　to　gallic　acid　(GA),　the　resulting　iron　(Fe)–GA　nanoparticles　(NPs)　proved　effective　as　a　T1-weighted　MRI　contrast　agent.　T98G　CM–coated　Fe–GA　NPs　demonstrated　improved　homotypic　glioma　targeting,　validated　through　Prussian　blue　staining　and　in　vitro　MRI.　This　biomimetic　camouflage　strategy　holds　promise　for　the　development　of　targeted　theranostic　agents　in　a　safe　and　effective　manner.　©　2024　Chen　et　al.

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[ 1 ] [Chen Y.]Fujian Key Laboratory of Toxicant and Drug Toxicology, Ningde Normal University, Fujian, Ningde, China
[ 2 ] [Chen Y.]Medical School, Ningde Normal University, Fujian, Ningde, China
[ 3 ] [Zhang Z.]Fujian Key Laboratory of Toxicant and Drug Toxicology, Ningde Normal University, Fujian, Ningde, China
[ 4 ] [Zhang Z.]Medical School, Ningde Normal University, Fujian, Ningde, China
[ 5 ] [Zhang Z.]Department of Chemistry, Fuzhou University, Fujian, Fuzhou, China
[ 6 ] [Chen Z.]Functional and Molecular Imaging Laboratory for Cerebral Vascular Diseases, Ningde Municipal Hospital of Ningde Normal University, Fujian, Ningde, China
[ 7 ] [Chen Z.]Radiology Department, Ningde Municipal Hospital of Ningde Normal University, Fujian, Ningde, China
[ 8 ] [Jiang S.]Pharmacy Department, Ningde Municipal Hospital of Ningde Normal University, Fujian, Ningde, China
[ 9 ] [Reheman A.]Fujian Key Laboratory of Toxicant and Drug Toxicology, Ningde Normal University, Fujian, Ningde, China
[ 10 ] [Reheman A.]Medical School, Ningde Normal University, Fujian, Ningde, China
[ 11 ] [Ouyang Y.]Fujian Key Laboratory of Toxicant and Drug Toxicology, Ningde Normal University, Fujian, Ningde, China
[ 12 ] [Ouyang Y.]Medical School, Ningde Normal University, Fujian, Ningde, China
[ 13 ] [Yu B.]Functional and Molecular Imaging Laboratory for Cerebral Vascular Diseases, Ningde Municipal Hospital of Ningde Normal University, Fujian, Ningde, China
[ 14 ] [Yu B.]Radiology Department, Ningde Municipal Hospital of Ningde Normal University, Fujian, Ningde, China
[ 15 ] [Chen Q.]Functional and Molecular Imaging Laboratory for Cerebral Vascular Diseases, Ningde Municipal Hospital of Ningde Normal University, Fujian, Ningde, China
[ 16 ] [Chen Q.]Radiology Department, Ningde Municipal Hospital of Ningde Normal University, Fujian, Ningde, China
[ 17 ] [Wei D.]Functional and Molecular Imaging Laboratory for Cerebral Vascular Diseases, Ningde Municipal Hospital of Ningde Normal University, Fujian, Ningde, China
[ 18 ] [Wei D.]Radiology Department, Ningde Municipal Hospital of Ningde Normal University, Fujian, Ningde, China

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PLoS ONE

ISSN： 1932-6203

Year： 2024

Issue： 7 July

Volume： 19

2 . 9 0 0

JCR@2023

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 1

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