In　this　study,　an　analytical　method　based　on　gas　chromatography-mass　spectrometry　(GC-MS)　was　developed　for　the　simultaneous　determination　of　8　common　psychoactive　substances　derived　from　cathinone　compounds　in　tea.　Extraction,　clean-up　and　chromatographic　and　mass　spectrometric　conditions　were　optimized.　As　a　result,　an　alkaline　solution　containing　methanol　was　selected　as　the　extraction　solvent,　and　the　extract　was　cleaned　up　on　an　HLB　solid-phase　extraction　(SPE)　cartridge　filled　with　N-propylethylenediamine　(PSA)　and　separated　on　a　DB-17MS　capillary　column　(30　m　×　0.25　mm,　0.25　μm).　The　mass　spectrometer　was　operated　using　an　electrospray　ionization　(EI)　source　in　the　selected　ion　monitoring　(SIM)　mode.　The　calibration　curves　showed　good　linearity　for　the　8　analytes　in　the　concentration　range　of　0–200　μg/L,　with　correlation　coefficients　(R2)　higher　than　0.998.　The　limits　of　detection　(LOD,　RSN　=　3)　and　limits　of　quantification　(LOQ,　RSN　=　10)　were　7　and　25　μg/kg,　respectively.　The　recoveries　from　negative　samples　spiked　at　1　×,　2　×　and　10　×　LOQ　were　in　the　range　of　67.2%–117.6%,　with　relative　standard　deviations　(RSD)　of　4.3%–12.3%　(n　=　6).　In　summary,　this　method　has　good　stability　and　high　sensitivity,　and　is　suitable　for　simultaneous　determination　of　the　psychoactive　substances　derived　from　cathinones　in　tea.　©　2024　Chinese　Chamber　of　Commerce.　All　rights　reserved.