Green Late-Stage Functionalization of Tryptamines - Details

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Abstract：

An　efficient　and　rapid　protocol　for　the　oxidative　halogenation　of　tryptamines　with　10　%　aqueous　NaClO　has　been　developed.　This　reaction　is　featured　by　its　operational　simplicity,　metal-free　conditions,　no　purification,　and　high　yield.　Notably,　the　resulting　key　intermediates　are　suitable　for　further　functionalization　with　various　nucleophiles,　including　amines,　N-aromatic　heterocycles,　indoles　and　phenols.　The　overall　transformation　exhibits　broad　functional-group　tolerance　and　is　applicable　to　the　late-stage　functionalization　of　complex　biorelevant　molecules.　©　2024　Wiley-VCH　GmbH.

Keyword：

Autophagy Drug discovery Green chemistry Late-stage functionalization Tryptamines

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[ 1 ] [Xu J.]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Zhang Y.]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Cai Q.]Fujian Provincial Key Laboratory of Medical Instrument and Pharmaceutical Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, 350108, China
[ 4 ] [Chen L.]Fujian Provincial Key Laboratory of Medical Instrument and Pharmaceutical Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, 350108, China
[ 5 ] [Sun Y.]School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350122, China
[ 6 ] [Liu Q.]School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350122, China
[ 7 ] [Gao Y.]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 8 ] [Chen H.]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou, 350108, China

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Green Late-Stage Functionalization of Tryptamines
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Source ：

Chemistry - A European Journal

ISSN： 0947-6539

Year： 2024

Issue： 46

Volume： 30

3 . 9 0 0

JCR@2023

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 2

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