Given　the　widespread　occurrence　of　pandemic　influenza,　antiviral　drugs　(ATVs)　as　emerging　pollutants　which　are　ubiquitously　present　in　wastewater　and　become　concentrated　in　sewage　sludge　(SS).　Therefore,　achieving　the　simultaneous　elimination　of　ATVs　during　sludge　dewatering　holds　significant　importance.　Herein,　six　representative　ATVs　including　amantadine,　rimantadine,　memantine　hydrochloride,　imiquimod,　oseltamivir,　and　morpholidine　were　detected　in　sewage　sludge.　Their　partitioning　between　solid　and　liquid　phases　was　also　examined　under　simultaneous　sludge　conditioning　by　particle　electrodes-assisted　electrochemical　process　(3D-SAC).　The　findings　indicated　that　3D-SAC　significantly　enhanced　sludge　dewaterability,　achieving　a　moisture　content　reduction　to　64.22　%.　The　total　removal　rates　of　the　six　ATVs　ranged　from　17.97　%　to　66.22　%,　closely　associated　with　the　degree　of　sludge　cells　cracking.　Sludge　lysis　resulted　in　the　destruction　of　protein-like　EPS　structures,　exposing　hydrophobic　bonding　sites,　finally　releasing　more　bonded　water　and　ATVs　into　filtrate.　The　·OH　induced　hydroxylation,　backbone　cleavage,　and　ring-opening　of　ATVs　occurred　concurrently　as　the　sludge　flocs　disrupted　and　structural　transformed.　Environmental　risk　assessment　revealed　that　the　ecological　risks　and　potential　toxicity　associated　with　the　sludge　filtrate　were　significantly　diminished　following　electrochemical　conditioning　(EC).　This　process　achieved　the　dual　objectives　of　contaminant　degradation　and　enhanced　sludge　dewatering.　©　2024　Elsevier　Ltd