Inspired　by　the　formation　of　natural　abalone　shells　(AS)　similar　to　calcium　salt　deposition　in　human　orthodontics,　AS　is　used　as　an　emulsifier　in　the　scaffold　to　solve　the　problem　of　coexistence　of　natural　and　synthetic　polymers　and　promote　new　bone　formation.　In　this　study,　AS-stabilized　and　reinforced　carboxymethyl　chitosan/collagen/PLGA　porous　bionic　composite　scaffolds　(AS/CMCS/Col/PLGA)　were　fabricated　through　the　emulsion　polymerization　and　bionic　hybrid　technology.　As　the　addition　of　AS　increased　from　0.75　to　3.0　wt%,　homogeneous　distribution　of　flower-like　particles　could　be　observed　on　the　inner　surface　of　the　scaffold,　and　its　mechanical　properties　were　improved.　Particularly,　3.0　wt%　AS-doped　scaffolds　(S3　and　C　+　S3)　exhibited　excellent　inorganic　mineral　deposition　and　osteoblast　proliferation　and　differentiation　abilities　in　vitro.　In　a　SD　rat　calvarial　defect　model,　they　effectively　promoted　new　bone　formation　in　the　defect　and　accelerated　expression　of　osteogenic-angiogenic　related　proteins　(COLI,　OCN,　VEGF).　By　virtue　of　its　combined　merits　including　good　mechanical　properties,　inducing　mineralization　crystallization　and　facilitating　osteogenesis,　the　3.0　wt%　AS-doped　scaffold　promises　to　be　employed　as　a　novel　bone　repair　material　for　bone　tissue　regeneration.　©　2024　Elsevier　B.V.