Long-afterglow　materials　have　a　broad　of　applications　in　optoelectronic　devices,　sensors,　medicine　and　other　fields　due　to　their　excellent　luminescent　properties.　The　host-guest　long-afterglow　MOFs　material　combines　the　advantages　of　multi-component　characteristics　and　the　stability　of　MOFs,　which　improves　its　luminous　performance　and　expands　its　other　properties.　This　review　introduces　the　classification,　synthesis　and　application　of　host-guest　MOFs　materials　with　long　afterglow.　Due　to　their　rigid　frames　and　multi-channel　characteristics,　MOFs　can　load　common　guest　materials　including　rare　earth　metals,　organic　dyes,　carbon　dots,　etc.　The　synthesis　methods　of　loading　guest　materials　into　MOFs　include　solvothermal　synthesis,　post-encapsulation,　post-modification,　etc.　Those　long-afterglow　host-guest　MOFs　have　a　wide　range　of　applications　in　the　fields　of　sensors,　information　security　and　biological　imaging.