The　coupling　between　anammox　and　nitrate/nitrite-dependent　anaerobic　methane　oxidation　(n-DAMO)　has　been　considered　a　sustainable　technology　for　nitrogen　removal　from　sidestream　wastewater　and　can　be　implemented　in　both　membrane　biofilm　reactor　(MBfR)　and　granular　bioreactor.　However,　the　potential　influence　of　the　accompanying　hydrogen　sulfide　(H　2　S)　in　the　anaerobic　digestion　(AD)-related　methane-containing　mixture　on　anammox/n-DAMO　remains　unknown.　To　fill　this　gap,　this　work　first　constructed　a　model　incorporating　the　C/　N/S-related　bioprocesses　and　evaluated/calibrated/validated　the　model　using　experimental　data.　The　model　was　then　used　to　explore　the　impact　of　H2S　on　the　MBfR　and　granular　bioreactor　designed　to　perform　anammox/nDAMO　at　practical　levels　(i.e.,　0-5%　(v/v)　and　0-40　g/S　m　3　,　respectively).　The　simulation　results　indicated　that　H2S　in　inflow　gas　did　not　significantly　affect　the　total　nitrogen　(TN)　removal　of　the　MBfR　under　all　operational　conditions　studied　in　this　work,　thus　lifting　the　concern　about　applying　AD-produced　biogas　to　power　up　anammox/n-DAMO　in　the　MBfR.　However,　the　presence　of　H2S　in　the　influent　would　either　compromise　the　treatment　performance　of　the　granular　bioreactor　at　a　relatively　high　influent　NH　4　+　-N/NO2-N　ratio　(e.g.,　＞1.0)　or　lead　to　increased　energy　demand　associated　with　TN　removal　at　a　relatively　low　influent　NH4+-N/NO2-N　ratio　(e.　g.,　＜0.7).　Such　a　negative　effect　of　the　influent　H　2　S　could　not　be　attenuated　by　regulating　the　hydraulic　residence　time　and　should　therefore　be　avoided　when　applying　the　granular　bioreactor　to　perform　anammox/n-DAMO　in　practice.