Fluorescence　fluctuation-based　super-resolution　microscopy　(FF-SRM)　is　an　economical　and　widely　applicable　technique　that　significantly　enhances　the　spatial　resolution　of　fluorescence　imaging　by　capitalizing　on　fluorescence　intermittency.　However,　each　variant　of　FF-SRM　imaging　has　inherent　limitations.　This　study　proposes　a　super-resolution　reconstruction　strategy　(synSRM)　by　synergizing　multiple　variants　of　the　FF-SRM　approach　to　address　the　limitations　and　achieve　high-quality　and　high-resolution　imaging.　The　simulation　and　experimental　results　demonstrate　that,　compared　to　images　reconstructed　using　single　FF-SRM　algorithms,　by　selecting　suitable　synSRM　routes　according　to　various　imaging　conditions,　further　improvements　of　the　spatial　resolution　and　image　reconstruction　quality　can　be　obtained　for　super-resolution　fluorescence　imaging.　©　2024　Optica　Publishing　Group　under　the　terms　of　the　Optica　Open　Access　Publishing　Agreement.