Reduction　of　nitric　acid　reaction　(2NO　+　HNO3　+　3CH3OH　→　3CH3ONO　+　2H2O)　can　convert　by-product　nitric　acid　into　raw　material　methyl　nitrite　in　the　coal　to　ethylene　glycol　(CTEG)　technology.　This　not　only　realizes　the　efficient　recycling　of　nitrogen　resources　but　also　plays　a　crucial　role　in　mitigating　environmental　pollution.　Despite　being　a　promising　catalyst,　the　Pd/C　catalyst　face　challenges　due　to　its　high　metal　loading,　substantial　loss　rate,　and　consequent　issues　of　poor　stability,　presenting　obstacles　in　meeting　industrial　requirements.　To　address　this　issue,　a　defect　strategy　has　been　employed　to　develop　a　low-loaded　0.3%　Pd/NC　catalyst　with　robust　metal-support　interaction,　resulting　in　a　significant　enhancement　of　catalyst　stability.　Remarkably,　even　after　undergoing　five　cycles,　the　catalyst　maintains　a　high　nitric　acid　conversion　rate　of　90%.　This　improved　performance　can　be　attributed　to　the　strong　metal-support　interaction　driven　by　electron　transfer　from　the　nitrogen-doped　carbon　(NC)　substrate　to　the　Pd　nanoparticles　evident　in　the　Transmission　electron　microscopy　(TEM),　X-ray　photoelectron　spectroscopy　(XPS),　and　inductively　coupled　plasma　(ICP)　results.　This　interaction　effectively　suppresses　the　leaching　of　the　active　Pd　nanoparticles,　leading　to　significantly　enhanced　stability　and　a　noticeable　reduction　in　the　loss　rate.　Raman　spectrum　and　electron　paramagnetic　resonance　(EPR)　results　can　further　reveal　that　the　increase　in　the　defect　density　lead　to　the　strong　metal-support　interaction　after　nitrogen　doping　(pyridinic-N-dominated).　These　findings　highlight　the　significant　potential　of　the　Pd/NC　catalyst　and　its　applicability　in　expediting　the　industrialization　process　of　catalyst.　Graphical　Abstract:　(Figure　presented.)　©　The　Author(s),　under　exclusive　licence　to　Springer　Science+Business　Media,　LLC,　part　of　Springer　Nature　2024.