Ti6Al4V　(TC4)　powders　of　dense　and　homogenous　microstructures　with　hcp　α-Ti　phase　prepared　by　electrode　induction　gas　atomization　(EIGA)　and　radio　frequency　(RF)　plasma　spheroidization　technologies　were　compared　based　on　compositional,　microstructural　and　micromechanical　characterization.　TC4　powders　prepared　by　EIGA　exhibit　larger　particle　sizes　and　better　sphericity　than　those　by　RF　due　to　the　numerous　tiny　satellite　particles　on　the　surface　of　powders　by　RF.　XPS　spectra　show　that　EIGA　produces　less　metal　carbonate　and　more　metal　oxide　on　the　surface　of　TC4　powders.　Nanoindentation　tests　show　that　elastic　modulus　EIT　and　indentation　hardness　HIT　of　TC4　powders　prepared　by　RF　are　larger　than　those　by　EIGA　due　to　the　larger　contents　of　N,　O,　and　H　elements　and　the　larger　average　domain　size　Dv　of　powders　prepared　by　RF.　Deep　Symbolic　Optimization　(DSO)　algorithm　was　employed　to　quantify　the　dependences　of　EIT　and　HIT　on　compositional　and　microstructural　parameters.　©　2024　Elsevier　B.V.