The　rapid　recombination　rate　of　photoexcited　carriers　for　iron　titanate　(FeTiO3)　is　still　limited　the　process　performance　of　photo-Fenton.　This　article　reports　the　successful　synthesis　of　the　highly　efficient　Z-scheme　FeTiO3/MOF-derived　In2S3　photocatalyst　using　the　hydrothermal　method,　compensating　for　the　susceptibility　of　FeTiO3　photo-generated　carriers　to　complexation　to　a　certain　extent.　A　series　of　characterization　have　been　carried　out　to　explore　the　structure,　morphology　and　composition　of　FeTiO3/MOF-derived　In2S3　heterostructure.　The　0.5　FeTiO3/MOF-derived　In2S3　exhibits　the　excellent　photo-Fenton　performance　for　TCH,　Cr6+　and　OTC,　the　degradation　rate　constants　(k2)　are　up　to　0.6297　L·mg−1·min−1,　1.332　L·mg−1·min−1,　and　0.427　L·mg−1·min−1,　respectively.　Active　species　capture　experiments　and　electron　paramagnetic　resonance　(EPR)　spectra　show　that　photo-generated　holes　(h+)　and　superoxide　radicals　(·O2-)　are　present　in　the　photo-Fenton　system.　The　superior　photo-Fenton　performance　is　mainly　manifested　in　the　following:　the　MOF-derived　In2S3　micro-floral　carrier　extends　the　reaction　interface　of　0.5　FM-I;　FeTiO3　effectively　enhances　the　photo-absorption　ability　of　0.5　FM-I　in　visible　range;　the　construction　of　Z-scheme　FeTiO3/MOF-derived　In2S3,　forming　the　new　carriers　transport　channels　and　enhancing　the　generation　of　·O2-　and　·OH.　This　experimental　exploration　provided　a　reasonable　experimental　basis　for　the　preparation　of　efficient　photocatalysts.　©　2024　Elsevier　B.V.