A　series　of　2D/2D　MoS2/Bi2WO6　S-scheme　heterojunctions　consisting　of　ultrathin　MoS2　nanosheets　(MS,　1.6　nm)　and　ultrathin　Bi2WO6　nanosheets　(BWO,　1.5　nm)　were　developed　for　photocatalytic　degradation　of　ciprofloxacin.　The　samples　with　5　%　mass　ratio　of　MS　(5　%MS/BWO)　exhibits　the　almost　complete　degradation　of　ciprofloxacin　(≈100　%)　under　visible　light.　It　is　evidenced　that　the　formation　of　S-scheme　heterojunction　with　close　interfacial　interaction　facilitates　the　photoinduced　carrier　separation　and　the　generation　of　surface　acid　sites.　The　activation　of　ciprofloxacin　molecules　is　realized　through　the　coordinately　interaction　of　C-N　and　C=O　with　the　surface　W　sites.　Moreover,　the　OVs　in　BWO　side　is　a　convenient　pathway　for　activated　of　O2,　embodying　in　the　generation　of　•O2−　and　•OH　under　visible　light　over　photocatalyst.　Such　an　association　of　charge　transfer　mechanism　with　coordination　activation　shows　the　enhanced　photocatalytic　performance　toward　ciprofloxacin.　This　work　provides　a　motivation　which　designs　an　S-scheme　heterojunction　photocatalyst　with　the　ability　to　activate　the　specific　group　in　molecules　to　comprehend　the　degradation　of　antibiotics.　©　2024　Elsevier　B.V.